Anti-inflammatory components isolated from Atractylodes macrocephala Koidz

被引：119
作者：
Dong, Haiyan [1 ]
He, Langchong
Huang, Meng [2 ]
Dong, Yalin [1 ]
机构：
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Coll Med, Dept Pharm, Xian 710049, Peoples R China
[2] Natl Univ Singapore, Dept Pharm, Singapore 117548, Singapore
来源：
NATURAL PRODUCT RESEARCH | 2008年 / 22卷 / 16期
关键词：
Atractylodis macrocephalae; anti-inflammatory effects; atractylenolide III; atractylenolide I; 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol; 14-acetoxy-12-alpha-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol; 14-acetoxy-12-beta-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol;
D O I：
10.1080/14786410801931629
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The petroleum ether-ether (1 : 1) extract of Atractylodis macrocephalae was screened by cell membrane chromatography (CMC) and subsequently separated by column chromatography (CC) and high performance liquid chromatography (HPLC). Five components were isolated and identified as atractylenolide III 1, atractylenolide I 2, 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol 3, 14-acetoxy-12-alpha-methylbutyl-2E,8E,10E-trien4,6-diyn-1-ol 4 and 14-acetoxy-12-beta-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 5 by routine spectrometric methods. The data of 5 and C-13-NMR data of 3 and 4 were reported for the first time. Further in vivo experiments showed that the five components exhibited significant inhibiting effects both on the ear edema induced by xylene and on the peritoneal capillary permeability induced by acetic acid in mice.
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页码：1418 / 1427
页数：10
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