Antidyslipidemic and antioxidant activity of the constituents isolated from the leaves of Calophyllum inophyllum

被引：34

作者：

Prasad, Janki ^{[1
]}

Shrivastava, Atul ^{[2
]}

Khanna, A. K. ^{[2
]}

Bhatia, G. ^{[2
]}

Awasthi, S. K. ^{[3
]}

Narender, T. ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, UP, India

[2] CSIR Cent Drug Res Inst, Div Biochem, Lucknow 226001, UP, India

[3] HBTI, Kanpur, Uttar Pradesh, India

来源：

PHYTOMEDICINE | 2012年 / 19卷 / 14期

关键词：

Calophyllum inophyllum; Antidyslipidemic activity; Triton model; Antioxidant activity; DERIVATIVES; CHOLESTEROL; INHIBITORS; TREE;

D O I：

10.1016/j.phymed.2012.09.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In continuation of our drug discovery program on Indian medicinal plants, we isolated bioactive compounds (1-5) from the leaves of Calophyllum inophyllum and evaluated their antidyslipidemic activity in triton induced hyperlipidemia model. The calophyllic acid (1A) and isocalophyllic acid (1B) mixture, canophyllic acid (4) and amentoflavone (5) showed dose dependent lipid lowering activity in in vivo experiments. The compounds 1A + 1B mixture and 3 also showed good in vitro antioxidant activity. (C) 2012 Elsevier GmbH. All rights reserved.

引用

页码：1245 / 1249

页数：5

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