Lanthanide-doped upconversion nanoparticles for biological super-resolution fluorescence imaging

被引：22

作者：

Xu, Rong ^{[1
]}

Cao, Huiqun ^{[2
]}

Lin, Danying ^{[1
]}

Yu, Bin ^{[1
]}

Qu, Junle ^{[1
]}

机构：

[1] Shenzhen Univ, Coll Phys & Optoelectron Engn, Key Lab Optoelectron Devices Syst, Minist Educ & Guangdong Prov, Shenzhen 518060, Peoples R China

[2] Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China

来源：

CELL REPORTS PHYSICAL SCIENCE | 2022年 / 3卷 / 06期

基金：

中国国家自然科学基金;

关键词：

STRUCTURED ILLUMINATION MICROSCOPY; ENERGY-TRANSFER; STIMULATED-EMISSION; RESOLUTION LIMIT; LUMINESCENCE; NANOCRYSTALS; THERAPEUTICS; NANOPROBES; TM3+;

D O I：

10.1016/j.xcrp.2022.100922

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Super-resolution fluorescence microscopy is a powerful, non-invasive tool to visualize subcellular structures and probe the dynamics of biomolecules in real time. Owing to their properties of stable multicolor emissions, large anti-Stokes shifts, tunable luminescence lifetimes, and good biocompatibility, lanthanide-doped upconversion nanoparticles (UCNPs) have gained popularity as fluorescent probes for super-resolution microscopy. In this review, we summarize the optical and biological properties of UCNPs and their applications in super-resolution fluorescence microscopy. By comparing the imaging performance of the latest strategies, we highlight that continuing efforts should focus on manipulating upconversion emissions, synthesizing smaller particles with bright luminescence, and integrating UCNPs with different imaging modes to meet the requirements of biological super-resolution imaging.

引用

页数：15

共 85 条

[61] Crystal structure of a neutralizing human IgG against HIV-1: A template for vaccine design [J].