Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine

被引：72

作者：

Sandrini, G

Cecchini, AP

Milanov, I

Tassorelli, C

Buzzi, MG

Nappi, G

机构：

[1] Univ Pavia, Lab Pain Psychophysiol, Dept Neurol Sci,IRCCS,C Mondino Fdn, Ctr Adapt Disorders & Headache, I-27100 Pavia, Italy

[2] Univ Sofia, Neurol Hosp, BU-1126 Sofia, Bulgaria

[3] IRCCS Neuromed, Headache Ctr, Pozzilli, IS, Italy

[4] Univ Roma La Sapienza, Inst Nervous & Mental Dis, Rome, Italy

来源：

NEUROSCIENCE LETTERS | 2002年 / 317卷 / 03期

关键词：

migraine; trigeminal pain pathway; corneal reflex; pain perception; tactile perception; blink reflex;

D O I：

10.1016/S0304-3940(01)02447-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The electrically elicited corneal reflex is a useful tool for exploring the trigeminal system in humans and it may provide additional evidence pointing to a dysfunction of this system in migrainous patients. Tactile perception, corneal reflex and pain thresholds were studied in 48 migraine without aura patients during pain-free periods and compared with those observed in 24 controls. Twenty-eight of the patients had strictly unilateral headache, while the other 20 had bilateral or side-shifting pain during attacks. Both migraine subgroups (bilateral and unilateral) showed significantly lower thresholds compared with controls. The lowest values were observed on the symptomatic side of unilateral migraine patients. These findings suggest that sensorimotor mechanisms and/or pain control systems at the trigeminal level are impaired in migraine. The bilateral location of these abnormalities seems to point to a centrally located dysfunction. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 138

页数：4

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