Active Achilles tendon kinesitherapy accelerates Achilles tendon repair by promoting neurite regeneration

被引：6
|
作者：
Jielile, Jiasharete [1 ,2 ]
Aibai, Minawa [3 ]
Sabirhazi, Gulnur [4 ]
Shawutali, Nuerai [1 ,2 ]
Tangkejie, Wulanbai [1 ,2 ]
Badelhan, Aynaz [1 ,2 ]
Nuerduola, Yeermike [1 ,2 ]
Satewalede, Turde [1 ,2 ]
Buranbai, Darehan [1 ,2 ]
Hunapia, Beicen [1 ,2 ]
Jialihasi, Ayidaer [1 ,2 ]
Bai, Jingping [5 ]
Kizaibek, Murat [6 ]
机构：
[1] Xinjiang Med Univ, Teaching Hosp 1, Dept Microsurg Repair & Reconstruct, Urumqi 830054, Xinjiang Uyghur, Peoples R China
[2] Res Inst Orthoped Xinjiang Uyghur Autonomous Reg, Sports Med Res Ctr, Urumqi 830054, Xinjiang Uyghur, Peoples R China
[3] Urumqi Ctr Dis Control & Prevent, Urumqi 830026, Xinjiang Uyghur, Peoples R China
[4] Chinese Acad Sci, Xinjiang Inst Ecol & Geog, Urumqi 830011, Xinjiang Uyghur, Peoples R China
[5] Xinjiang Med Univ, Teaching Hosp 3, Dept Orthoped, Urumqi 830011, Xinjiang Uyghur, Peoples R China
[6] Res Inst Kazakh Tradit Med Ili Kazakh Autonomous, Yining 835000, Ili Kazakh Auto, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 35期
基金：
中国国家自然科学基金;
关键词：
achilles tendon rupture; early; motion; functional exercise; exercise; Achilles tendon; healing; proteomics; marker; tissue repair; SURGICAL REPAIR; FUNCTIONAL TREATMENT; RUPTURE; PROTEINS; GELSOLIN; CRMP-2; REHABILITATION; IMMOBILIZATION; WEIGHTBEARING; PROTEOMICS;
D O I：
10.3969/j.issn.1673-5374.2012.35.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achilles tendon rupture. The tendon was then immobilized or subjected to postoperative early motion treatment (kinesitherapy). Mass spectrography results showed that after 14 days of motion treatment, 18 protein spots were differentially expressed, among which, 12 were up-regulated, consisting of gelsolin isoform b and neurite growth-related protein collapsing response mediator protein 2. Western blot analysis showed that gelsolin isoform b was up-regulated at days 7-21 of motion treatment. These findings suggest that active Achilles tendon kinesitherapy promotes the neurite regeneration of a ruptured Achilles tendon and gelsolin isoform b can be used as a biomarker for Achilles tendon healing after kinesitherapy.
引用
收藏
页码：2801 / 2810
页数：10
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