Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria

被引：6

作者：

Wang, Jia ^{[1
]}

Li, Ting ^{[1
]}

Li, Mengling ^{[1
]}

Fu, Zhendong ^{[1
]}

Chen, Likai ^{[3
]}

Shi, Dongxing ^{[1
]}

Qiu, Fubin ^{[1
]}

Tan, Xintong ^{[2
,4
]}

机构：

[1] Shanxi Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Taiyuan, Shanxi, Peoples R China

[2] Shandong Agr Univ, Coll Food Sci & Engn, Tai An, Shandong, Peoples R China

[3] Washington State Univ, Elson S Floyd Coll Med, Spokane, WA USA

[4] Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271000, Shandong, Peoples R China

来源：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY | 2022年 / 110卷

基金：

中国国家自然科学基金;

关键词：

FGF21; Mitochondrion; Insulin signal transduction; Lycopene; D; -galactose; SEX-DIFFERENCES; D-GALACTOSE; NEUROINFLAMMATION; AMPK; SUPPLEMENTATION; SIRT1;

D O I：

10.1016/j.jnutbio.2022.109144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lycopene (LYC) has been regarded as a nutraceutical that has powerful antioxidant and hepatoprotective bioactivities. In the present study, we aimed to investigate the beneficial effects of LYC on hepatic insulin signal transduction under oxidative stress conditions and the possible involvement of FGF21 and mitochondria pathways. Two-month-old CD-1 mice were treated by intraperitoneal injection of D-galactose (D-gal) 150 mg/kg/day for 8 weeks and received 0.03% LYC (w/w, mixed into diet). The results showed that LYC increased the expression of FGF21, alleviated mitochondrial dysfunction and improved hepatic insulin signal transduction in D-gal-treated mice. Furthermore, knockdown of FGF21 by small interfering RNA notably suppressed mitochondrial function and blunted LYC-stimulated insulin signal transduction in H2O2-treated HepG2 cells. Moreover, suppressed mitochondrial function via oligomycin also inhibited insulin signal transduction, indicating that LYC supplementation ameliorated oxidative stress-induced hepatic dysfunction of insulin signal transduction by up-regulating FGF21 and enhancing mitochondrial function. (c) 2022 Elsevier Inc. All rights reserved.

引用

页数：11