Generation of unnatural α,α-disubstituted amino acid derivatives from cyclic sulfamidates

被引：47

作者：

Boulton, LT ^{[1
]}

Stock, HT ^{[1
]}

Raphy, J ^{[1
]}

Horwell, DC ^{[1
]}

机构：

[1] Univ Cambridge, Parke Davis Neurosci Res Ctr, Cambridge CB2 2QB, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 11期

关键词：

D O I：

10.1039/a901667h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclic sulfamidates function as excellent precursors to a variety of unnatural alpha,alpha-disubstituted amino acid derivatives by ring opening with a suitable nucleophile. Addition of various nucleophiles to a sulfamidate derived from 2-methylserine is described.

引用

页码：1421 / 1429

页数：9

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