PALLADIUM-CATALYZED SYNTHESIS OF A PHOSPHINE OXIDE WITH A CHIRAL PHOSPHORUS CENTER VIA C-H PHOSPHINATION

被引：14

作者：

Kuninobu, Yoichiro ^{[1
]}

Origuchi, Kazuki ^{[1
]}

Takai, Kazuhiko ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biotechnol, Kita Ku, Okayama 7008530, Japan

来源：

HETEROCYCLES | 2012年 / 85卷 / 12期

关键词：

C-H Activation; Chiral Phosphorus Center; Palladium; Phosphination; Phosphine Oxide; LIGANDS; HYDROGENATION; CYCLIZATION;

D O I：

10.3987/COM-12-12595

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new phosphine oxide with a chiral phosphine center was synthesized from a bis(biphenyl)phosphine oxide by dehydrogenative intramolecular cyclization via P-H and C-H bond activation under palladium catalysis. The absolute configuration of one enantiomer of the phosphine oxide was determined by single crystal X-ray structure analysis. By reducing the phosphine oxide, the corresponding phosphine, which also has a chiral center, was produced. The phosphine compounds could be optically resolved by chiral HPLC column chromatography.

引用

页码：3029 / 3034

页数：6

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