Leishmanicidal Activity of Two Naphthoquinones against Leishmania donovani

被引：26

作者：

Lezama-Davila, Claudio Manuel ^{[1
]}

Patricia Isaac-Marquez, Angelica ^{[2
]}

Kapadia, Govind ^{[3
]}

Owens, Katherine ^{[4
]}

Oghumu, Steve ^{[1
]}

Beverley, Stephen ^{[4
]}

Satoskar, Abhay Rajaninath ^{[1
]}

机构：

[1] Ohio State Univ, Dept Pathol, Wexner Med Ctr, Columbus, OH 43210 USA

[2] Univ Autonoma Campeche, Ctr Invest Enfermedades Trop, Campeche 24030, Mexico

[3] Howard Univ, Sch Pharm, Dept Pharmaceut Sci, Washington, DC 20059 USA

[4] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2012年 / 35卷 / 10期

关键词：

Leishmania; naphthoquinone; macrophage; CHEMOTHERAPY; DERIVATIVES; RESISTANCE; PLUMBAGIN;

D O I：

10.1248/bpb.b12-00419

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Here we studied ability of two naphthoquinones to inhibit Leishmania growth (2,3-dichloro-5,8-dihydroxy-1,4-naphthoquinone (TR 001) and 2,3-dibromo-1,4-naphthoquinone (TR 002). TR 001 was more efficient than TR 002 in inducing killing of promastigotes and intracellular amastigotes. These values compare well to those obtained with the standard first-line antileishmanial agent sodium stibogluconate (SSG). TR 001 also induced significantly more nitric oxide (NO) production than TR 002 or SSG. Taken together, these data show that TR 001 and TR 002 could be promising new drugs for treatment of visceral leishmaniasis.

引用

页码：1761 / 1764

页数：4

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