Supported copper triflate as an efficient catalytic system for the synthesis of highly functionalized 2-naphthol Mannich bases under solvent free condition

被引：45

作者：

Dindulkar, Someshwar D. ^{[1
]}

Puranik, Vedavati G. ^{[2
]}

Jeong, Yeon Tae ^{[1
]}

机构：

[1] Pukyong Natl Univ, Dept Image Sci & Engn, Pusan 608737, South Korea

[2] Natl Chem Lab, Ctr Mat Characterizat, Pune 400008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 33期

关键词：

Three-component coupling; Betti bases; Supported copper triflate; Single-crystal XRD; Solvent-free; DOMINO MULTICOMPONENT REACTION; BETTI-BASE; DERIVATIVES; WATER; POT;

D O I：

10.1016/j.tetlet.2012.06.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various heterogeneous catalysts (Lewis acid) have been prepared and screened for the synthesis of Betti bases in an attempt to reduce the environmental hazards associated with the conventional homogeneous Lewis acid system. And we found especially Cu(OTf)(2)center dot SiO2 catalyzes the three-component coupling of aldehyde, 2-naphthol, and alicyclic amine to generate Betti base with high efficiency under neat conditions without additional co-catalyst or additive in air. The reaction is not sensitive to water and occurs smoothly in water as well. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4376 / 4380

页数：5

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