Design, Synthesis and Biological Evaluation of Caffeic Acid Amides as Selective MMP-2 and MMP-9 Inhibitors

被引：12

作者：

Shi, Zhi-Hao ^{[1
,3
]}

Li, Nian-Guang ^{[1
,2
]}

Shi, Qian-Ping ^{[1
,2
]}

Tang, Hao ^{[1
]}

Tang, Yu-Ping ^{[1
]}

Li, Wei ^{[1
,2
]}

Yin, Lian ^{[1
]}

Yang, Jian-Ping ^{[1
]}

Duan, Jin-Ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol Res TCM Formulae, Nanjing 210046, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Dept Med Chem, Nanjing 210046, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, Dept Organ Chem, Nanjing 211198, Jiangsu, Peoples R China

来源：

DRUG DEVELOPMENT RESEARCH | 2012年 / 73卷 / 06期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

metrix metalloproteinase; caffeic acid; tumor; structure-activity relationship; MATRIX-METALLOPROTEINASE INHIBITOR; PHENETHYL ESTER; INTERSTITIAL COLLAGENASE; CATALYTIC DOMAIN; METASTASIS; CLEAVAGE; EXTRACT; DISEASE; ANALOGS; CANCER;

D O I：

10.1002/ddr.21038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Strategy, Management and Health Policy Preclinical Research A series of caffeic acid amides with extended P1' groups were synthesized and tested for their inhibitory activities on matrix metalloproteinase (MMP)-1, MMP-2, and MMP-9. Compound 3f showed considerable inhibitory activities against MMP-2, MMP-9, and best selectivity over MMP-1. Preliminary structureactivity relationship analysis and docking studies indicated that caffeic acid amides with electron-donating groups at p-position of amino phenyl group showed better inhibitory activities and selectivity than those with electron-withdrawing groups. The findings of this study would provide information for the exploitation and utilization of caffeic acid as MMP inhibitor for metastatic tumor treatment.

引用

页码：343 / 351

页数：9

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