Diffusion-Weighted Imaging, MR Angiography, and Baseline Data in a Systematic Multicenter Analysis of 3,301 MRI Scans of Ischemic Stroke Patients-Neuroradiological Review Within the MRI-GENIE Study

被引：6

作者：

Drake, Mattias ^{[1
,2
]}

Frid, Petrea ^{[3
,4
]}

Hansen, Bjorn M. ^{[1
,2
]}

Wu, Ona ^{[5
]}

Giese, Anne-Katrin ^{[6
,7
]}

Schirmer, Markus D. ^{[6
,8
]}

Donahue, Kathleen ^{[6
]}

Cloonan, Lisa ^{[6
]}

Irie, Robert E. ^{[5
]}

Bouts, Mark J. R. J. ^{[5
]}

McIntosh, Elissa C. ^{[5
]}

Mocking, Steven J. T. ^{[5
]}

Dalca, Adrian V. ^{[5
,9
]}

Sridharan, Ramesh ^{[9
]}

Xu, Huichun ^{[10
]}

Giralt-Steinhauer, Eva ^{[11
]}

Holmegaard, Lukas ^{[12
]}

Jood, Katarina ^{[12
]}

Roquer, Jaume ^{[11
]}

Cole, John W. ^{[13
,14
]}

McArdle, Patrick F. ^{[10
]}

Broderick, Joseph P. ^{[15
]}

Jimenez-Conde, Jordi ^{[11
]}

Jern, Christina ^{[16
]}

Kissela, Brett M. ^{[15
]}

Kleindorfer, Dawn O. ^{[15
]}

Lemmens, Robin ^{[17
,18
]}

Meschia, James F. ^{[19
]}

Rundek, Tatjana ^{[20
,21
]}

Sacco, Ralph L. ^{[20
,21
]}

Schmidt, Reinhold ^{[22
]}

Sharma, Pankaj ^{[23
,24
]}

Slowik, Agnieszka ^{[25
]}

Thijs, Vincent ^{[26
,27
]}

Woo, Daniel ^{[15
]}

Worrall, Bradford B. ^{[28
,29
]}

Kittner, Steven J. ^{[13
,14
]}

Mitchell, Braxton D. ^{[10
,30
]}

Rosand, Jonathan ^{[5
,6
,31
,32
]}

Golland, Polina ^{[9
]}

Lindgren, Arne ^{[33
,34
]}

Rost, Natalia S. ^{[6
]}

Wasselius, Johan ^{[1
,2
]}

机构：

[1] Lund Univ, Dept Clin Sci Lund, Radiol, Lund, Sweden

[2] Skane Univ Hosp, Dept Radiol, Neuroradiol, Lund, Sweden

[3] Lund Univ, Dept Clin Sci Lund, Neurol, Lund, Sweden

[4] Skane Univ Hosp, Dept Neurol & Rehabil Med, Neurol, Malmo, Sweden

[5] Harvard Med Sch, Massachusetts Gen Hosp MGH, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA USA

[6] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

[7] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA

[8] German Ctr Neurodegenerat Dis DZNE, Dept Populat Hlth Sci, Bonn, Germany

[9] MIT, Comp Sci & Artificial Intelligence Lab, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[10] Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA

[11] Univ Autonoma Barcelona, IMIM Hosp del Mar Inst Hosp Mar Invest Med, Neurovasc Res Grp NEUVAS, Dept Neurol, Barcelona, Spain

[12] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden

[13] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

[14] Vet Affairs Maryland Hlth Care Syst, Baltimore, MD USA

[15] Univ Cincinnati, Coll Med, Dept Neurol & Rehabil Med, Cincinnati, OH USA

[16] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Lab Med, Gothenburg, Sweden

[17] Expt Neurol & Leuven Res Inst Neurosci & Dis LIND, Dept Neurosci, Leuven, Belgium

[18] Univ Hosp Leuven, VIB, Neurobiol Lab, Vesalius Res Ctr,Dept Neurol, Leuven, Belgium

[19] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA

[20] Univ Miami, Dept Neurol, Miami, FL USA

[21] Univ Miami, Miller Sch Med, Evelyn F McKnight Brain Inst, Miami, FL 33136 USA

[22] Med Univ Graz, Dept Neurol, Clin Div Neurogeriatr, Graz, Austria

[23] Royal Holloway Univ London ICR2UL, Inst Cardiovasc Res, Egham, Surrey, England

[24] Ashford & St Peters Hosp, Surrey, England

[25] Jagiellonian Univ, Dept Neurol, Coll Med, Krakow, Poland

[26] Florey Inst Neurosci & Mental Hlth, Stroke Div, Heidelberg, Vic, Australia

[27] Austin Hlth, Dept Neurol, Heidelberg, Vic, Australia

[28] Univ Virginia, Dept Neurol, Charlottesville, VA USA

[29] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA

[30] Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, Baltimore, MD 21218 USA

[31] Massachusetts Gen Hosp, Henry & Allison McCancer Ctr Brain Hlth, Boston, MA USA

[32] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA USA

[33] Lund Univ, Dept Clin Sci Lund, Neurol, Lund, Sweden

[34] Skane Univ Hosp, Neurol, Dept Neurol & Rehabil Med, Lund, Sweden

来源：

FRONTIERS IN NEUROLOGY | 2020年 / 11卷

关键词：

stroke; imaging; MRI; phenotype; DWI; BRAIN; CIRCULATION; DESIGN; CT;

D O I：

10.3389/fneur.2020.00577

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background:Magnetic resonance imaging (MRI) serves as a cornerstone in defining stroke phenotype and etiological subtype through examination of ischemic stroke lesion appearance and is therefore an essential tool in linking genetic traits and stroke. Building on baseline MRI examinations from the centralized and structured radiological assessments of ischemic stroke patients in the Stroke Genetics Network, the results of the MRI-Genetics Interface Exploration (MRI-GENIE) study are described in this work. Methods:The MRI-GENIE study included patients with symptoms caused by ischemic stroke (N= 3,301) from 12 international centers. We established and used a structured reporting protocol for all assessments. Two neuroradiologists, using a blinded evaluation protocol, independently reviewed the baseline diffusion-weighted images (DWIs) and magnetic resonance angiography images to determine acute lesion and vascular occlusion characteristics. Results:In this systematic multicenter radiological analysis of clinical MRI from 3,301 acute ischemic stroke patients according to a structured prespecified protocol, we identified that anterior circulation infarcts were most prevalent (67.4%), that infarcts in the middle cerebral artery (MCA) territory were the most common, and that the majority of large artery occlusions 0 to 48 h from ictus were in the MCA territory. Multiple acute lesions in one or several vascular territories were common (11%). Of 2,238 patients with unilateral DWI lesions, 52.6% had left-sided infarct lateralization (P= 0.013 for chi(2)test). Conclusions:This large-scale analysis of a multicenter MRI-based cohort of AIS patients presents a unique imaging framework facilitating the relationship between imaging and genetics for advancing the knowledge of genetic traits linked to ischemic stroke.

引用

页数：7

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