Public health genomics and personalized prevention: lessons from the COGS project

被引：20
作者：
Pashayan, N. [1 ]
Hall, A. [2 ]
Chowdhury, S. [2 ]
Dent, T. [2 ]
Pharoah, P. D. P. [3 ,4 ]
Burton, H. [2 ]
机构：
[1] UCL, Dept Appl Hlth Res, London WC1E 6BT, England
[2] PHG Fdn, Cambridge, England
[3] Univ Cambridge, Dept Oncol, Cambridge, England
[4] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England
来源：
JOURNAL OF INTERNAL MEDICINE | 2013年 / 274卷 / 05期
关键词：
ethical; legal and social issues; personalized prevention; polygenic risk stratification; public health genomics; screening; BREAST-CANCER; POLYGENIC SUSCEPTIBILITY; PROSTATE; PREDICTION; SURVIVAL; RISK;
D O I：
10.1111/joim.12094
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Using the principles of public health genomics, we examined the opportunities and challenges of implementing personalized prevention programmes for cancer at the population level. Our model-based estimates indicate that polygenic risk stratification can potentially improve the effectiveness and cost-effectiveness of screening programmes. However, compared with one-size-fits-all' screening programmes, personalized screening adds further layers of complexity to the organization of screening services and raises ethical, legal and social challenges. Before polygenic inheritance is translated into population screening strategy, evidence from empirical research and engagement with and education of the public and the health professionals are needed.
引用
收藏
页码：451 / 456
页数：6
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