This paper takes the opto-electronic information industry cluster in East Lake High-tech Zone as the research object. Firstly, we depicted the development status quo of electronic information industry cluster. Based on which, we then analyzed the problems in the opto-electronic information industry cluster including lack of coordination and linkage mechanism, short in prospective studies, poor stability of the backbone R&D personnel, and lack of benign soft environment which is essential for the development of industrial cluster. Finally, we put forward countermeasures and suggestions from perspectives of building basic research and development platform, improving the industry chain of opto-electronic technological innovation, stabilizing the backbone of R&D personnel, and establishing supermarket platform of professional service.