Tumor-on-a-chip platforms for assessing nanoparticle-based cancer therapy

被引：18

作者：

Wang, Yimin ^{[1
,2
,3
]}

Cuzzucoli, Fabio ^{[1
,2
,3
,4
]}

Escobar, Andres ^{[1
,2
,3
,4
]}

Lu, Siming ^{[1
,2
,3
]}

Liang, Liguo ^{[1
,2
,3
]}

Wang, ShuQi ^{[1
,2
,3
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

[2] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Zhejiang, Peoples R China

[4] Univ Waterloo, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada

来源：

NANOTECHNOLOGY | 2018年 / 29卷 / 33期

关键词：

tumor-on-a-chip; nanoparticles; cancer therapy; MAGNETIC NANOPARTICLES; LUNG-CANCER; CLINICAL TRANSLATION; ANIMAL-MODELS; MICROENVIRONMENT; DELIVERY; CELL; HYPERTHERMIA; RADIOTHERAPY; METASTASIS;

D O I：

10.1088/1361-6528/aac7a4

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Cancer has become the most prevalent cause of deaths, placing a huge economic and healthcare burden worldwide. Nanoparticles (NPs), as a key component of nanomedicine, provide alternative options for promoting the efficacy of cancer therapy. Current conventional cancer models have limitations in predicting the effects of various cancer treatments. To overcome these limitations, biomimetic and novel 'tumor-on-a-chip' platforms have emerged with other innovative biomedical engineering methods that enable the evaluation of NP-based cancer therapy. In this review, we first describe cancer models for evaluation of NP-based cancer therapy techniques, and then present the latest advances in 'tumor-on-a-chip' platforms that can potentially facilitate clinical translation of NP-based cancer therapies.

引用

页数：11

共 72 条

[1] Tumour-on-a-chip provides an optical window into nanoparticle tissue transport [J].