Salicylic acid protects the skin from UV damage

被引：0

作者：

Mammone, Thomas ^{[1
]}

Gan, David ^{[1
]}

Goyarts, Earl ^{[1
]}

Maes, Daniel ^{[1
]}

机构：

[1] Estee Lauder Co, Melville, NY USA

来源：

JOURNAL OF COSMETIC SCIENCE | 2006年 / 57卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Aspirin (acetyl salicylate) has long been used as an analgesic. Salicylic acid has previously been reported to have antiinflammatory properties. These activities include inhibiting activity of cox-1, cox-2, and NF-kb. In addition, salicylic acid has also been shown in some systems to induce Hsp70. We have demonstrated that salicylic acid inhibits UVB-induced NF-kb activation in keratinocytes. In addition, salicylic acid was also found to induce Hsp 70 in keratinocytes and increase keratinocyte survival to UVB toxicity. In living skin equivalents, salicylic acid was found to reduce UVB induced sunburn cell formation, as well as increase the removal of UVB induced TT dimer formation in living skin equivalents. Given these protective properties of salicylic acid, we propose the use of salicylic acid as a topical therapeutic to protect the skin from sun damage.

引用

页码：203 / 204

页数：2

共 10 条

[1]

Al Mahroos M, 2002, ARCH DERMATOL, V138, P1480

[2] An essential role for NF-kappa B in preventing TNF-alpha-induced cell death [J].