Predictive Factors for Disease Progression in Patients With Early-Onset Alzheimer's Disease

被引：15

作者：

Yoon, Bora ^{[1
]}

Shim, Yong S. ^{[2
]}

Park, Hee-Kyung ^{[3
]}

Park, Sun Ah ^{[4
]}

Choi, Seong Hye ^{[5
]}

Yang, Dong Won ^{[6
]}

机构：

[1] Konyang Univ, Coll Med, Konyang Univ Hosp, Dept Neurol, Taejon, South Korea

[2] Catholic Univ Korea, Coll Med, Bucheon St Marys Hosp, Dept Neurol, Bucheon, South Korea

[3] Inje Univ, Ilsan Paik Hosp, Dept Neurol, Goyang, South Korea

[4] Soonchunhyang Univ, Bucheon Hosp, Dept Neurol, Bucheon, South Korea

[5] Inha Univ, Sch Med, Dept Neurol, Inchon, South Korea

[6] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Neurol, Seoul 137040, South Korea

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2016年 / 49卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Alzheimer's disease; cognitive reserve; disease progression; early-onset; education; longitudinal study; E EPSILON-4 ALLELE; COGNITIVE RESERVE; CLINICAL CHARACTERISTICS; FUNCTIONAL CONNECTIVITY; DEMENTIA; DECLINE; REGISTRY; RATES; AGE; IMPAIRMENT;

D O I：

10.3233/JAD-150462

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Only a fewstudies have investigated disease progression in patients with early-onset Alzheimer's disease (EOAD). Therefore, the aim of this study was to investigate disease progression in patients with EOAD and the influence of various factors, such as gender, education, and apolipoprotein E (APOE) genotype on disease progression. Methods: A total of 288 EOAD patients were enrolled in the study. Linear mixed models were used to investigate the rate of cognitive and functional decline in terms of age at onset, gender, education, follow-up period, and APOE genotype. Results: EOAD patients showed an annual decline of -1.54 points/years in the Korean version mini-mental examination score, an annual increase of 3.46 points/year in the Seoul instrumental activities of daily living (SIADL) score, and an annual increase of 1.15 points/year in the clinical dementia rating scale-sum of boxes score. After stratification, higher educated patients showed faster disease progression in all three parameters, and female patients demonstrated faster disease progression as assessed by the SIADL score. Age at onset and APOE genotype had no influence on disease progression. Conclusion: We confirmed the rate of disease progression in Korean patients with EOAD in real-life hospital-based clinical practice. The results of this study suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with EOAD.

引用

页码：85 / 91

页数：7

共 47 条

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