Access to chiral tetrahydrofluorenes through a palladium-catalyzed enantioselective tandem intramolecular Heck/Tsuji-Trost reaction

被引：29

作者：

Zhang, Ying ^{[1
]}

Shen, Hong-Cheng ^{[1
]}

Li, Yang-Yang ^{[1
]}

Huang, Yong-Shuang ^{[2
]}

Han, Zhi-Yong ^{[1
]}

Wu, Xiang ^{[2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

[2] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, 193 Tunxi Rd, Hefei 230009, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 26期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC HECK REACTION; NONCONJUGATED DIENES; ARYL IODIDES; DITERPENES; 1,2-DIFUNCTIONALIZATION; CYCLIZATION; LIGANDS; CARBON;

D O I：

10.1039/c9cc01379b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed enantioselective coupling of 2,5-cyclohexadienyl-substituted aryl iodides and carbon or heteroatom nucleophiles is described. The reaction proceeded via a tandem asymmetric Heck insertion and Tsuji-Trost allylation, enabling the rapid construction of valuable chiral tetrahydrofluorenes by using a chiral H8-BINOL-based phosphoramidite ligand.

引用

页码：3769 / 3772

页数：4

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