LncRNAs and miRNAs: potential biomarkers and therapeutic targets for prostate cancer

被引：1

作者：

Ma, Guoxing ^{[1
,2
,3
,4
]}

Tang, Mingqing ^{[1
,2
,4
]}

Wu, Yaqing ^{[1
,2
,3
]}

Xu, Xiaoming ^{[1
,2
]}

Pan, Feng ^{[1
,2
]}

Xu, Ruian ^{[1
,2
,3
,4
]}

机构：

[1] Minist Educ, Engn Res Ctr Mol Med, Xiamen, Peoples R China

[2] Huaqiao Univ, Sch Biomed Sci, Xiamen, Peoples R China

[3] Key Lab Xiamen Marine & Gene Drugs, Xiamen, Peoples R China

[4] Key Lab Fujian Mol Med, Xiamen 361021, Peoples R China

来源：

AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2016年 / 8卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Prostate cancer; lncRNA; miRNA; diagnosis; therapeutic target; LONG NONCODING RNA; ANDROGEN-RECEPTOR; STEM-CELLS; MESENCHYMAL TRANSITION; EPIGENETIC REGULATION; HOTAIR; METASTASIS; MICRORNA; MALAT1; GENE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer (PCa) is the second lethal disease for men in western countries. Although androgen receptor (AR) signaling has been widely investigated, noncoding RNAs (ncRNAs), deficient of open reading frame, have also received considerable attention. Growing studies showed that the aberrant ncRNAs expression contributed to cell proliferation, metastasis and drug resistance in PCa. Therefore, therapeutically targeting ncRNAs may synergize androgen deprivation therapy (ADT) to have a better effect to fight against PCa, especially castration-resistant prostate cancer (CRPC). This review would systematically summarize the multicellular events controlled by ncRNAs and give a snapshot of future scientific activities and clinical applications.

引用

页码：5141 / 5150

页数：10

共 60 条

[1] Mortality Results from a Randomized Prostate-Cancer Screening Trial [J].

Andriole, Gerald L. ;

Grubb, Robert L., III ;

Buys, Saundra S. ;

Chia, David ;

Church, Timothy R. ;

Fouad, Mona N. ;

Gelmann, Edward P. ;

Kvale, Paul A. ;

Reding, Douglas J. ;

Weissfeld, Joel L. ;

Yokochi, Lance A. ;

Crawford, E. David ;

O'Brien, Barbara ;

Clapp, Jonathan D. ;

Rathmell, Joshua M. ;

Riley, Thomas L. ;

Hayes, Richard B. ;

Kramer, Barnett S. ;

Izmirlian, Grant ;

Miller, Anthony B. ;

Pinsky, Paul F. ;

Prorok, Philip C. ;

Gohagan, John K. ;

Berg, Christine D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) :1310-1319

[2] Critical Assessment of Preoperative Urinary Prostate Cancer Antigen 3 on the Accuracy of Prostate Cancer Staging [J].

Auprich, Marco ;

Chun, Felix K. -H. ;

Ward, John F. ;

Pummer, Karl ;

Babaian, Richard ;

Augustin, Herbert ;

Luger, Ferdinand ;

Gutschi, Stefan ;

Budaeus, Lars ;

Fisch, Margit ;

Huland, Hartwig ;

Graefen, Markus ;

Haese, Alexander .

EUROPEAN UROLOGY, 2011, 59 (01) :96-105

[3] The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells [J].

Bianchessi, Valentina ;

Badi, Ileana ;

Bertolotti, Matteo ;

Nigro, Patrizia ;

D'Alessandra, Yuri ;

Capogrossi, Maurizio C. ;

Zanobini, Marco ;

Pompilio, Giulio ;

Raucci, Angela ;

Lauri, Andrea .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2015, 81 :62-70

[4] MiR-130a, miR-203 and miR-205 jointly repress key oncogenic pathways and are downregulated in prostate carcinoma [J].

Boll, K. ;

Reiche, K. ;

Kasack, K. ;

Moerbt, N. ;

Kretzschmar, A. K. ;

Tomm, J. M. ;

Verhaegh, G. ;

Schalken, J. ;

von Bergen, M. ;

Horn, F. ;

Hackermueller, J. .

ONCOGENE, 2013, 32 (03) :277-285

[5] Noncoding RNAs in Prostate Cancer: The Long and the Short of It [J].

Bolton, Eva M. ;

Tuzova, Alexandra V. ;

Walsh, Anna L. ;

Lynch, Thomas ;

Perry, Antoinette S. .

CLINICAL CANCER RESEARCH, 2014, 20 (01) :35-43

[6] The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities [J].

Bonci, Desiree ;

Coppola, Valeria ;

Musumeci, Maria ;

Addario, Antonio ;

Giuffrida, Raffaella ;

Memeo, Lorenzo ;

D'Urso, Leonardo ;

Pagliuca, Alfredo ;

Biffoni, Mauro ;

Labbaye, Catherine ;

Bartucci, Monica ;

Muto, Giovanni ;

Peschle, Cesare ;

De Maria, Ruggero .

NATURE MEDICINE, 2008, 14 (11) :1271-1277

[7]

Bussemakers MJG, 1999, CANCER RES, V59, P5975

[8] International Variation in Prostate Cancer Incidence and Mortality Rates [J].

Center, Melissa M. ;

Jemal, Ahmedin ;

Lortet-Tieulent, Joannie ;

Ward, Elizabeth ;

Ferlay, Jacques ;

Brawley, Otis ;

Bray, Freddie .

EUROPEAN UROLOGY, 2012, 61 (06) :1079-1092

[9] Long Non-coding RNA HOTAIR Is Targeted and Regulated by miR-141 in Human Cancer Cells [J].

Chiyomaru, Takeshi ;

Fukuhara, Shinichiro ;

Saini, Sharanjot ;

Majid, Shahana ;

Deng, Guoren ;

Shahryari, Varahram ;

Chang, Inik ;

Tanaka, Yuichiro ;

Enokida, Hideki ;

Nakagawa, Masayuki ;

Dahiya, Rajvir ;

Yamamura, Soichiro .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (18) :12550-12565

[10] TGF-β-Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12 [J].

Fan, Yu ;

Shen, Bing ;

Tan, Mingyue ;

Mu, Xinyu ;

Qin, Yan ;

Zhang, Fang ;

Liu, Yong .

CLINICAL CANCER RESEARCH, 2014, 20 (06) :1531-1541

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