Review in Quantitative Structure Activity Relationships on Lipoxygenase Inhibitors

被引：9

作者：

Eleni, Pontiki ^{[1
]}

Dimitra, Hadjipavlou-Litina ^{[1
]}

机构：

[1] Aristotelian Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 05期

关键词：

QSAR; LOX inhibitors; lipophilicity; steric factors; electronic effects;

D O I：

10.2174/1389557033487999

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper reviews and evaluates all the published QSAR treatments of LOX inhibitors. This reveals that in almost all cases, the clog P parameter plays an important part in the QSAR relationships. In some cases the steric factors (B-1, B-5 and L) as well as the overall molar refractivity (CMR) or the substitutents molar refractivity (MR) are important. Electronic effects except for the Hammet's constant sigma, are comparatively unimportant. The study shows that log P as calculated from the Clog P program is suitable for this form of QSAR study. Log Po of 2.77-3.76 was found to be ideal, for the biological response.

引用

页码：487 / 499

页数：13

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