Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones.: Cytotoxic activity against ras-transformed cells

被引：62
作者：
Quiroga, AG
Pérez, JM
Montero, EI
West, DX
Alonso, C
Navarro-Ranninger, C [1 ]
机构：
[1] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Inorgan, E-28049 Madrid, Spain
[2] Illinois State Univ, Dept Chem, Normal, IL 61790 USA
[3] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 1999年 / 75卷 / 04期
关键词：
Pd(II) complexes; Pt(II) complexes; thiosemicarbazones; cytotoxic activity;
D O I：
10.1016/S0162-0134(99)00102-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cytotoxicity tests in tumor cells sensitive to cis-DDP (HL-60, JURKAT,Hela and 3T3) and in tumor cells transformed by ras oncogenes and resistant to cis-DDP (Pam 212-ras) show that cyclometallated complexes 1a [Pd(p-is.TSCN-NHMe) ](4,) 2b [Pt(p-is.TSCN-NMe2)](4) and 4a [Pd(p-is.TSCN-NHex) ](4) may be endowed with specific cytotoxic properties. In fact, these three novel metal-thiosemicarbazone compounds kill Pam 212-ras cells through apoptosis induction. These results. together with others recently published, indicate that the design and synthesis of metallated-thiosemicarbazone compounds may lead to the discovery of novel antitumor agents able to circumvent cis-DDP resistance, in particular tumor cell lines. (C) 1999 Elsevier Science Inc. All rights reserved.
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收藏
页码：293 / 301
页数：9
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