Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

被引：455

作者：

Zhao, Chuang ^{[1
]}

Rakesh, K. P. ^{[1
]}

Ravidar, L. ^{[1
]}

Fang, Wan-Yin ^{[1
]}

Qin, Hua-Li ^{[1
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Dept Pharmaceut Engn, 205 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 162卷

基金：

中国国家自然科学基金;

关键词：

Sulfonyl (S-VI); Sulfonamides; SAR; Docking; Biological activities; CARBONIC-ANHYDRASE INHIBITORS; STRUCTURE-BASED DESIGN; BEARING BENZENE SULFONAMIDE; TARGET-DIRECTED LIGANDS; HIV PROTEASE INHIBITORS; IN-VITRO EVALUATION; BIOLOGICAL EVALUATION; ALZHEIMERS-DISEASE; MOLECULAR DOCKING; 5-HT6; RECEPTOR;

D O I：

10.1016/j.ejmech.2018.11.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sulfur (S-VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have showed a variety of pharmacological properties, and its derivatives propose a high degree of structural diversity that has established useful for the finding of new therapeutic agents. The developments of new less toxic, low cost and highly active sulfonamides containing analogues are hot research topics in medicinal chemistry. Currently, more than 150 FDA approved Sulfur (S-VI)-based drugs are available in the market, and they are widely used to treat various types of diseases with therapeutic power. This comprehensive review highlights the recent developments of sulfonyl or sulfonamides based compounds in huge range of therapeutic applications such as antimicrobial, anti-inflammatory, antiviral, anticonvulsant, antitubercular, antidiabetic, antileishmanial, carbonic anhydrase, antimalarial, anticancer and other medicinal agents. We believe that, this review article is useful to inspire new ideas for structural design and developments of less toxic and powerful Sulfur (S-VI) based drugs against the numerous death-causing diseases. (C) 2018 Elsevier Masson SAS. All rights reserved.

引用

页码：679 / 734

页数：56

共 251 条

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