SARS-CoV-2: diagnostic and design conundrums in the context of male factor infertility

被引：7

作者：

Bahadur, Gulam ^{[1
,2
]}

Acharya, Santanu ^{[3
]}

Muneer, Asif ^{[4
]}

Huirne, Judith ^{[5
,6
]}

Lukaszuk, Mariusz ^{[7
]}

Doreski, Pablo Alexis ^{[8
]}

Homburg, Roy ^{[2
]}

机构：

[1] North Middlesex Univ Hosp, Reprod Med Unit, London, England

[2] Homerton Univ Hosp, Homerton Fertil Ctr, London, England

[3] Univ Hosp Crosshouse, Ayrshire Fertil Unit, Kilmarnock, Scotland

[4] Univ Coll London Hosp, London, England

[5] Univ Med Ctr Amsterdam, Locat VUmc, Amsterdam, Netherlands

[6] AMC, Res Inst Reprod & Dev, Amsterdam, Netherlands

[7] NoweOrlowo Med Ctr, Gdynia, Poland

[8] FundacionRespirar, Buenos Aires, DF, Argentina

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2020年 / 41卷 / 03期

关键词：

COVID-19; Diagnosis; Infertility; Male factor; SARS-CoV-2; Semen; ORCHITIS;

D O I：

10.1016/j.rbmo.2020.05.014

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The question of whether SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus-2 [SARS-CoV-2], leading to the COVID-19 infection) can be harboured in the testes and/or semen is currently unanswered. It is essential to understand the limitations of both antibody and real-time PCR tests in interpreting SARS-CoV-2 data in relation to analyses of semen and testicular tissue without appropriate controls. This article critically analyses the evidence so far on this, and the possible implications. The limitations of diagnostic tests in both sampling and testing methodologies, their validation and their relevance in interpreting data are also highlighted.

引用

页码：365 / 369

页数：5

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