Corticotropin-Releasing Factor Receptors and Their Interacting Proteins: Functional Consequences

被引：16
|
作者：
Slater, Paula G. [1 ]
Yarur, Hector E. [1 ]
Gysling, Katia [1 ]
机构：
[1] Pontificia Univ Catolica Chile, Dept Cellular & Mol Biol, Fac Biol Sci, Santiago, Chile
来源：
MOLECULAR PHARMACOLOGY | 2016年 / 90卷 / 05期
关键词：
VENTRAL TEGMENTAL AREA; STRESS-INDUCED RELAPSE; PSEUDO SIGNAL PEPTIDE; CRF-BINDING-PROTEIN; COCAINE-SEEKING BEHAVIOR; COUPLED RECEPTOR; BETA-ARRESTIN2; RECRUITMENT; DOPAMINE NEURONS; VASOPRESSIN V1B; CELL-SURFACE;
D O I：
10.1124/mol.116.104927
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and anxiety disorders such as depression, acts through G-protein-coupled receptors (GPCRs) known as type-1 and type-2 CRF receptors. The purpose of this review is to highlight recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and their associated functional consequences. A better understanding of these interactions may generate new pharmacological alternatives for the treatment of addiction and stress-related disorders.
引用
收藏
页码：627 / 632
页数：6
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