Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines

被引：178
作者：
Egami, Hiromichi [1 ,2 ]
Kawamura, Shintaro [1 ,2 ]
Miyazaki, Ayako [1 ,2 ]
Sodeoka, Mikiko [1 ,2 ,3 ]
机构：
[1] RIKEN, Synthet Organ Chem Lab, Wako, Saitama 3510198, Japan
[2] Japan Sci & Technol Agcy, Sodeoka Live Cell Chem Project, ERATO, Wako, Saitama 3510198, Japan
[3] RIKEN Ctr Sustainable Resource Sci, Wako, Saitama 3510198, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 30期
关键词：
amines; aziridines; copper; multicomponent reactions; trifluoromethylation; COPPER-CATALYZED TRIFLUOROMETHYLATION; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; TERMINAL ALKENES; FLUORINE; EFFICIENT; OXYTRIFLUOROMETHYLATION; HYDROTRIFLUOROMETHYLATION; ALLYLSILANES; REAGENTS;
D O I：
10.1002/anie.201303350
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A multitalented system: N-Migratory oxytrifluoromethylation and one-pot three-component reactions of allylamines as well as the aminotrifluoromethylation of alkenyl amines all proceeded efficiently in the presence of the Togni reagent (1) and CuI to afford a variety of β-trifluoromethylamine derivatives (see scheme). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：7841 / 7844
页数：4
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