Trifluoromethylation Reactions for the Synthesis of β-Trifluoromethylamines

被引：179

作者：

Egami, Hiromichi ^{[1
,2
]}

Kawamura, Shintaro ^{[1
,2
]}

Miyazaki, Ayako ^{[1
,2
]}

Sodeoka, Mikiko ^{[1
,2
,3
]}

机构：

[1] RIKEN, Synthet Organ Chem Lab, Wako, Saitama 3510198, Japan

[2] Japan Sci & Technol Agcy, Sodeoka Live Cell Chem Project, ERATO, Wako, Saitama 3510198, Japan

[3] RIKEN Ctr Sustainable Resource Sci, Wako, Saitama 3510198, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 30期

关键词：

amines; aziridines; copper; multicomponent reactions; trifluoromethylation; COPPER-CATALYZED TRIFLUOROMETHYLATION; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; ELECTROPHILIC TRIFLUOROMETHYLATION; TERMINAL ALKENES; FLUORINE; EFFICIENT; OXYTRIFLUOROMETHYLATION; HYDROTRIFLUOROMETHYLATION; ALLYLSILANES; REAGENTS;

D O I：

10.1002/anie.201303350

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A multitalented system: N-Migratory oxytrifluoromethylation and one-pot three-component reactions of allylamines as well as the aminotrifluoromethylation of alkenyl amines all proceeded efficiently in the presence of the Togni reagent (1) and CuI to afford a variety of β-trifluoromethylamine derivatives (see scheme). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7841 / 7844

页数：4

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