Total oxidant, antioxidant, and paraoxonase levels in babies born to pre-eclamptic mothers

被引:9
作者
Altunhan, Huseyin [1 ]
Annagur, Ali [2 ]
Kurban, Sevil [3 ]
Ertugrul, Sabahattin [4 ]
Konak, Murat [4 ]
Ors, Rahmi [4 ]
机构
[1] Abant Izzet Baysal Univ, Dept Neonatol, Fac Med, Bolu, Turkey
[2] Selcuk Univ, Fac Med, Dept Neonatol, TR-42075 Konya, Turkey
[3] Necmettin Erbakan Univ, Meram Med Fac, Dept Clin Biochem, Konya, Turkey
[4] Necmettin Erbakan Univ, Meram Med Fac, Dept Neonatol, Konya, Turkey
关键词
antioxidant activity; newborn; oxidative stress; paraoxonase-1; total antioxidant status; total oxidant status; OXIDATIVE STRESS; LIPID-PEROXIDATION; XANTHINE-OXIDASE; BIRTH-WEIGHT; URIC-ACID; PREGNANCY; CAPACITY; PLASMA; GLUTATHIONE; DISEASES;
D O I
10.1111/jog.12026
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aim The aim of this study was to investigate the oxidant-antioxidant status in babies born to pre-eclamptic mothers (BBPM). Material and Methods The paraoxonase (PON)-1, total antioxidant status (TAS), and total oxidant status (TOS) levels were measured in the cord blood and venous blood (7th day) of BBPM (n=31) and babies born to normotensive mothers (n=25). Results The PON-1 and TOS levels in the cord blood and venous blood on the 7th day were not significantly different between the two groups; however, the cord blood TAS levels were higher in BBPM (P=0.001), and the TAS levels in the venous blood were higher in the control group (P=0.021). Furthermore, the cord blood PON-1 levels of babies born to severely pre-eclamptic mothers (n=18) were higher than those of babies born to moderately pre-eclamptic mothers (n=13) (P=0.042). There were no differences in the cord blood TAS and TOS levels and venous blood PON-1, TAS, and TOS levels between babies born to severely and moderately pre-eclamptic mothers. Conclusion The increased TAS levels found in the cord blood of BBPM indicate that the fetus is protected against oxidative damage caused by increased oxidative stress in the mother. To the best of our knowledge, this is the first study in the published work investigating PON-1 levels in BBPM.
引用
收藏
页码:898 / 904
页数:7
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