Optimal blockade of the renin-angiotensin-aldosterone system

被引:13
作者
Nussberger, Juerg [1 ]
Bohlender, Juergen [2 ]
机构
[1] CHU Vaudois, Dept Internal Med, Div Angiol & Hypertens, CH-1011 Lausanne, Switzerland
[2] Hop Fribourgeois, Med Clin, CH-1708 Fribourg, Switzerland
关键词
ALISKIREN; INHIBITION;
D O I
10.1038/nrcardio.2013.28
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inhibition of the renin-angiotensin-aldosterone system (RAAS) is a successful therapy for hypertension, heart failure, and renal insufficiency. Overdosing of RAAS inhibitors is occasionally observed when several agents are used together, and can cause adverse events such as hypotension, hyperkalaemia, and renal failure. We advocate optimal, rather than complete, RAAS blockade. Nussberger, J. & Bohlender, J. Nat. Rev. Cardiol. 10, 183-184 (2013); published online 12 March 2013; doi:10.1038/nrcardio.2013.28
引用
收藏
页码:183 / 184
页数:2
相关论文
共 50 条
[31]   Evolving understanding of the renin-angiotensin-aldosterone system: Pathophysiology and targets for therapeutic intervention [J].
Gradman, Alan H. .
AMERICAN HEART JOURNAL, 2009, 157 (06) :S1-S6
[32]   Cardiorenal disease development under chronic renin-angiotensin-aldosterone system suppression [J].
Sarafidis, Pantelis A. ;
Ruilope, Luis M. .
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2012, 13 (01) :217-219
[33]   Circulating renin-angiotensin-aldosterone system activity in cats with systemic hypertension or cardiomyopathy [J].
Ward, Jessica L. ;
Guillot, Emilie ;
Domenig, Oliver ;
Ware, Wendy A. ;
Yuan, Lingnan ;
Mochel, Jonathan P. .
JOURNAL OF VETERINARY INTERNAL MEDICINE, 2022, 36 (03) :897-909
[34]   Renin-angiotensin-aldosterone system gender differences in an Afro-Caribbean population [J].
Cohall, Damian H. ;
Scantlebury-Manning, Thea ;
James, Stephen ;
Hall, Kiana ;
Ferrario, Carlos M. .
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2015, 16 (03) :539-546
[35]   Azilsartan, Aliskiren, and Combination Antihypertensives Utilizing Renin-Angiotensin-Aldosterone System Antagonists [J].
Lanier, Gregg ;
Sankholkar, Kedar ;
Aronow, Wilbert S. .
AMERICAN JOURNAL OF THERAPEUTICS, 2014, 21 (05) :419-435
[36]   Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart Failure [J].
Amatruda, Jonathan G. ;
Scherzer, Rebecca ;
Rao, Veena S. ;
Ivey-Miranda, Juan B. ;
Shlipak, Michael G. ;
Estrella, Michelle M. ;
Testani, Jeffrey M. .
KIDNEY MEDICINE, 2022, 4 (06)
[37]   Comparative Risk for Angioedema Associated With the Use of Drugs That Target the Renin-Angiotensin-Aldosterone System [J].
Toh, Sengwee ;
Reichman, Marsha E. ;
Houstoun, Monika ;
Southworth, Mary Ross ;
Ding, Xiao ;
Hernandez, Adrian F. ;
Levenson, Mark ;
Li, Lingling ;
McCloskey, Carolyn ;
Shoaibi, Azadeh ;
Wu, Eileen ;
Zornberg, Gwen ;
Hennessy, Sean .
ARCHIVES OF INTERNAL MEDICINE, 2012, 172 (20) :1582-1589
[38]   Role of the renin-angiotensin-aldosterone system in diastolic heart failure: Potential for pharmacologic intervention [J].
Bernal J. ;
Pitta S.R. ;
Thatai D. .
American Journal of Cardiovascular Drugs, 2006, 6 (6) :373-381
[39]   Proteinuria and renin-angiotensin-aldosterone system blockers. New aspects of pathogenesis and therapy [J].
Lindner, T. H. .
DIABETOLOGE, 2013, 9 (08) :622-+
[40]   Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness [J].
Koumaras, Charalambos ;
Tziomalos, Konstantinos ;
Stavrinou, Eirini ;
Katsiki, Niki ;
Athyros, Vasilios G. ;
Mikhailidis, Dimitri P. ;
Karagiannis, Asterios .
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION, 2014, 8 (02) :74-82