PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

被引：1153
作者：
Finck, BN
Kelly, DP
机构：
[1] Washington Univ, Sch Med, Ctr Cardiovasc Res, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 03期
关键词：
D O I：
10.1172/JCI27794
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Members of the PPAR gamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
引用
收藏
页码：615 / 622
页数：8
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