Visible-Light-Induced External Radical-Triggered Annulation To Access CF2-Containing Benzoxepine Derivatives

被引：59

作者：

Xiang, Haoyue ^{[1
]}

Zhao, Qing-Lan ^{[1
]}

Xia, Peng-Ju ^{[1
]}

Xiao, Jun-An ^{[2
]}

Ye, Zhi-Peng ^{[1
]}

Xie, Xiong ^{[1
]}

Sheng, Huan ^{[1
]}

Chen, Xiao-Qing ^{[1
]}

Yang, Hua ^{[1
]}

机构：

[1] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China

[2] Guangxi Teachers Educ Univ, Coll Chem & Mat Sci, Nanning 530000, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 05期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

PHOTOREDOX CATALYSIS; FLUOROALKYLATION REACTIONS; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; ESTROGEN-RECEPTOR; ALKENES; ACIDS; CYCLIZATION; DIFLUOROALKYLATION; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.8b00131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and diversified synthesis of functionalized CF2-containing benzoxepine derivatives via photoredox catalysis was achieved in this work. This novel protocol features broad substrate scope, mild reaction conditions, operational simplicity, easy scale-up, and versatile derivatization, which would facilitate its practical and broad applications in the construction of valuable and synthetically challenging heterocycles.

引用

页码：1363 / 1366

页数：4

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