Visible-Light-Induced External Radical-Triggered Annulation To Access CF2-Containing Benzoxepine Derivatives

被引：58
作者：
Xiang, Haoyue [1 ]
Zhao, Qing-Lan [1 ]
Xia, Peng-Ju [1 ]
Xiao, Jun-An [2 ]
Ye, Zhi-Peng [1 ]
Xie, Xiong [1 ]
Sheng, Huan [1 ]
Chen, Xiao-Qing [1 ]
Yang, Hua [1 ]
机构：
[1] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China
[2] Guangxi Teachers Educ Univ, Coll Chem & Mat Sci, Nanning 530000, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 05期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
PHOTOREDOX CATALYSIS; FLUOROALKYLATION REACTIONS; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; ESTROGEN-RECEPTOR; ALKENES; ACIDS; CYCLIZATION; DIFLUOROALKYLATION; FUNCTIONALIZATION;
D O I：
10.1021/acs.orglett.8b00131
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and diversified synthesis of functionalized CF2-containing benzoxepine derivatives via photoredox catalysis was achieved in this work. This novel protocol features broad substrate scope, mild reaction conditions, operational simplicity, easy scale-up, and versatile derivatization, which would facilitate its practical and broad applications in the construction of valuable and synthetically challenging heterocycles.
引用
收藏
页码：1363 / 1366
页数：4
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