Peripheral nerve injury decreases the expression of metabolic glutamate receptor 7 in dorsal root ganglion neurons

被引：12

作者：

Li, Jian-You ^{[2
]}

Wang, Xiang ^{[3
]}

Ji, Peng-Tian ^{[3
]}

Li, Xiong-Feng ^{[2
]}

Guan, Guo-Hua ^{[2
]}

Jiang, Xue-Sheng ^{[2
]}

Zhou, Guo-shun ^{[2
]}

Hua, Feng ^{[3
]}

Wang, Nan ^{[1
]}

机构：

[1] Huzhou Tradit Chinese Med Hosp, Dept Med, Huzhou 313000, Peoples R China

[2] Huzhou Cent Hosp, Dept Orthoped, Huzhou 313000, Peoples R China

[3] Huzhou Cent Hosp, Huzhou Key Lab Mol Med, Huzhou 313000, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2012年 / 531卷 / 01期

基金：

中国国家自然科学基金;

关键词：

mGluR7; Dorsal root ganglion; Axotomy; Neuropathic pain; METABOTROPIC GLUTAMATE-RECEPTOR-7; NEUROPATHIC PAIN; DIFFERENTIAL EXPRESSION; SENSORY NEURONS; MESSENGER-RNA; RAT; AGONIST; HYPERALGESIA; NOCICEPTORS; DISCHARGE;

D O I：

10.1016/j.neulet.2012.10.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Group II and III metabolic glutamate receptors (mGluRs) are responsible for the glutamate-mediated postsynaptic excitation of neurons. Previous pharmacological evidences show that activation of mGluR7 could inhibit nociceptive reception. However, the distribution and expression patterns of mGluR7 after peripheral injury remain unclear. Herein we found that mGluR7 was expressed in the rat peptidergic dorsal root ganglion (DRG) neurons and large neurons, but rarely in isolectin B4 positive neurons. Sciatic nerve ligation experiment showed that mGluR7 was anterogradely transported from cell body to the peripheral site. Furthermore, after peripheral nerve injury, mGluR7 expression was down-regulated in both peptidergic and large DRG neurons. Our work suggests that mGluR7 might be involved in the regulation of pathological pain after peripheral nerve injury. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 56

页数：5

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