Design and Synthesis of "All-in-One" Multifunctional FeS2 Nanoparticles for Magnetic Resonance and Near-Infrared Imaging Guided Photothermal Therapy of Tumors

被引:88
作者
Meng, Zhouqi [1 ]
Wei, Fang [2 ]
Ma, Wujun [1 ]
Yu, Nuo [1 ]
Wei, Peiling [1 ]
Wang, Zhaojie [1 ]
Tang, Yueqin [2 ]
Chen, Zhigang [1 ]
Wang, Huiping [2 ]
Zhu, Meifang [1 ]
机构
[1] Donghua Univ, Coll Mat Sci & Engn, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China
[2] Shanghai Jiao Tong Univ, Peoples Hosp 1, Expt Res Ctr, Shanghai 201620, Peoples R China
基金
中国国家自然科学基金;
关键词
PHOTODYNAMIC THERAPY; CONTRAST AGENTS; CANCER-CELLS; COMPUTED-TOMOGRAPHY; W18O49; NANOWIRES; NANOCOMPOSITES; NANOCRYSTALS; ABLATION; SURFACE; VIVO;
D O I
10.1002/adfm.201603776
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The ideal theranostic nanoplatform for tumors is a single nanoparticle that has a single semiconductor or metal component and contains all multimodel imaging and therapy abilities. The design and preparation of such a nanoparticle remains a serious challenge. Here, with FeS2 as a model of a semiconductor, the tuning of vacancy concentrations for obtaining "all-in-one" type FeS2 nanoparticles is reported. FeS2 nanoparticles with size of approximate to 30 nm have decreased photoabsorption intensity from the visible to near-infrared (NIR) region, due to a low S vacancy concentration. By tuning their shape/size and then enhancing the S vacancy concentration, the photoabsorption intensity of FeS2 nanoparticles with size of approximate to 350 nm (FeS2-350) goes up with the increase of the wavelength from 550 to 950 nm, conferring the high NIR photothermal effect for thermal imaging. Furthermore, this nanoparticle has excellent magnetic properties for T-2-weighted magnetic resonance imaging (MRI). Subsequently, FeS2-350 phosphate buffer saline (PBS) dispersion is injected into the tumor-bearing mice. Under the irradiation of 915-nm laser, the tumor can be ablated and the metastasis lesions in liver suffer significant inhibition. Therefore, FeS2-350 has great potential to be used as novel "all-in-one" multifunctional theranostic nanoagents for MRI and NIR dual-modal imaging guided NIR-photothermal ablation therapy (PAT) of tumors.
引用
收藏
页码:8231 / 8242
页数:12
相关论文
共 55 条
[1]   Near-infrared dye bound albumin with separated imaging and therapy wavelength channels for imaging-guided photothermal therapy [J].
Chen, Qian ;
Wang, Chao ;
Zhan, Zhixiong ;
He, Weiwei ;
Cheng, Zhenping ;
Li, Youyong ;
Liu, Zhuang .
BIOMATERIALS, 2014, 35 (28) :8206-8214
[2]   Ultrathin PEGylated W18O49 Nanowires as a New 980 nm-Laser-Driven Photothermal Agent for Efficient Ablation of Cancer Cells In Vivo [J].
Chen, Zhigang ;
Wang, Qian ;
Wang, Huanli ;
Zhang, Lisha ;
Song, Guosheng ;
Song, Linlin ;
Hu, Junqing ;
Wang, Hongzhi ;
Liu, Jianshe ;
Zhu, Meifang ;
Zhao, Dongyuan .
ADVANCED MATERIALS, 2013, 25 (14) :2095-2100
[3]   Functional Nanomaterials for Phototherapies of Cancer [J].
Cheng, Liang ;
Wang, Chao ;
Feng, Liangzhu ;
Yang, Kai ;
Liu, Zhuang .
CHEMICAL REVIEWS, 2014, 114 (21) :10869-10939
[4]   PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual-Modal CT/Photoacoustic Imaging Guided Photothermal Therapy [J].
Cheng, Liang ;
Liu, Jingjing ;
Gu, Xing ;
Gong, Hua ;
Shi, Xiaoze ;
Liu, Teng ;
Wang, Chao ;
Wang, Xiaoyong ;
Liu, Gang ;
Xing, Huaiyong ;
Bu, Wenbo ;
Sun, Baoquan ;
Liu, Zhuang .
ADVANCED MATERIALS, 2014, 26 (12) :1886-1893
[5]   Anti-CD4-targeted Gold Nanoparticles Induce Specific Contrast Enhancement of Peripheral Lymph Nodes in X-ray Computed Tomography of Live Mice [J].
Eck, Wolfgang ;
Nicholson, Anthony I. ;
Zentgraf, Hanswalter ;
Semmler, Wolfhard ;
Bartling, Soenke .
NANO LETTERS, 2010, 10 (07) :2318-2322
[6]   Facile preparation of uniform FeSe2 nanoparticles for PA/MR dual-modal imaging and photothermal cancer therapy [J].
Fu, Tingting ;
Chen, Yuyan ;
Hao, Jiali ;
Wang, Xiaoyong ;
Liu, Gang ;
Li, Yonggang ;
Liu, Zhuang ;
Cheng, Liang .
NANOSCALE, 2015, 7 (48) :20757-20768
[7]   A Manganese Alternative to Gadolinium for MRI Contrast [J].
Gale, Eric M. ;
Atanasova, Iliyana P. ;
Blasi, Francesco ;
Ay, Ilknur ;
Caravan, Peter .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (49) :15548-15557
[8]   Engineering of Multifunctional Nano-Micelles for Combined Photothermal and Photodynamic Therapy Under the Guidance of Multimodal Imaging [J].
Gong, Hua ;
Dong, Ziliang ;
Liu, Yumeng ;
Yin, Shengnan ;
Cheng, Liang ;
Xi, Wenyao ;
Xiang, Jian ;
Liu, Kai ;
Li, Yonggang ;
Liu, Zhuang .
ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (41) :6492-6502
[9]   Dynamics of point defect formation, clustering and pit initiation on the pyrite surface [J].
Herbert, F. W. ;
Krishnamoorthy, A. ;
Ma, W. ;
Van Vliet, K. J. ;
Yildiz, B. .
ELECTROCHIMICA ACTA, 2014, 127 :416-426
[10]   Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy [J].
Hong, Guosong ;
Diao, Shuo ;
Antaris, Alexander L. ;
Dai, Hongjie .
CHEMICAL REVIEWS, 2015, 115 (19) :10816-10906