Regulatory networks determining substrate utilization in brown adipocytes

被引：6

作者：

Onogi, Yasuhiro ^{[1
,2
]}

Ussar, Siegfried ^{[1
,2
,3
]}

机构：

[1] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Helmholtz Diabet Ctr, Inst Diabet & Obes,RG Adipocytes & Metab, D-85764 Neuherberg, Germany

[2] German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany

[3] Tech Univ Munich, Dept Med, Munich, Germany

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2022年 / 33卷 / 07期

关键词：

ADIPOSE-TISSUE; ENERGY-EXPENDITURE; GLUCOSE-UPTAKE; DIURNAL RHYTHM; COLD; THERMOGENESIS; METABOLISM; INSULIN; FAT; GLYCOLYSIS;

D O I：

10.1016/j.tem.2022.04.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brown adipose tissue (BAT) is often considered as a sink for nutrients to generate heat. However, when the complex hormonal and nervous inputs and intracellular signaling networks regulating substrate utilization are considered, BAT appears much more as a tightly controlled rheostat, regulating body temperature and balancing circulating nutrient levels. Here we provide an overview of key regulatory circuits, including the diurnal rhythm, determining glucose, fatty acid, and amino acid utilization and the interdependency of these nutrients in thermogenesis. Moreover, we discuss additional factors mediating sympathetic BAT activation beyond beta-adrenergic signaling and the limitations of glucose-based BAT activity measurements to foster a better understanding and interpretation of BAT activity data.

引用

页码：493 / 506

页数：14

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