Effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats

被引：7

作者：

Vijayalakshmi, B. ^{[1
]}

Kumar, G. Suresh ^{[2
]}

Salimath, P. V. ^{[1
]}

机构：

[1] Cent Food Technol Res Inst, Dept Biochem & Nutr, Mysore 570020, Karnataka, India

[2] Daegu Univ, Dept Biotechnol, Gyongsan, South Korea

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2009年 / 23卷 / 01期

关键词：

Diabetic complication; Glycoconjugate metabolism; Fermentation of dietary fiber; Dietary fiber; Bitter gourd; Spent turmeric; HEPARAN-SULFATE; DIETARY-FIBERS; BUTYRIC-ACID; GLYCOSAMINOGLYCANS; CARBOHYDRATE; EXPRESSION; COMPONENTS; PLANT;

D O I：

10.1016/j.jdiacomp.2007.09.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: Changes in glycoconjugate metabolism during the development of diabetic complications and their modulation by feeding bitter gourd and spent turmeric as fiber-rich source. Method: This was Studied by measuring the contents of total Sugar, uronic acid, amino sugar, and sulfate in the streptozotocin-induced diabetic rats. Results: Total sugar content decreased in liver, spleen, and brain, while an increase was observed in heart and lungs. Uronic acid content in liver, spleen, and brain decreased, and marginal increase was observed in testis. Amino sugar content decreased in liver, spleen, lungs and heart during diabetes, and augmentation was observed to different extents. Decrease in sulfation of glycoconjugates was observed in liver, spleen, lungs and heart during diabetes and was significantly ameliorated by bitter gourd and spent turmeric, except brain. Protein content decreased in liver, while an increase was observed in brain. The studies clearly showed alteration in glycoconjugate metabolism during diabetes and amelioration to different extents by feeding bitter gourd and spent turmeric. Conclusion: Improvement is due to slow release Of glucose by fiber in the gastrointestinal track and short-chain fatty acid production from fiber by colon microbes. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：71 / 76

页数：6

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