Natural killers join the fight against cancer An antibody overcomes cancer cell immune evasion and activates natural killer cells

被引：37

作者：

Cerwenka, Adelheid ^{[1
,2
]}

Lanier, Lewis L. ^{[3
,4
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Ctr Biomed & Med Technol CBTM, Ludolf Krehl Str 13-17, D-68167 Mannheim, Germany

[2] Heidelberg Univ, Med Fac Mannheim, European Ctr Angiosci ECAS, Ludolf Krehl Str 13-17, D-68167 Mannheim, Germany

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Parker Inst Canc Immunotherapy, San Francisco, CA 94143 USA

来源：

SCIENCE | 2018年 / 359卷 / 6383期

关键词：

ANTITUMOR-ACTIVITY; DOWN-REGULATION; NKG2D RECEPTOR; CUTTING EDGE; NK CELLS; LIGANDS; EXPRESSION; PROTEIN;

D O I：

10.1126/science.aat2184

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：1460 / 1461

页数：2

共 15 条

[1] Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].

Bauer, Stefan ;

Groh, Veronika ;

Wu, Jun ;

Steinle, Alexander ;

Phillips, Joseph H. ;

Lanier, Lewis L. ;

Spies, Thomas .

JOURNAL OF IMMUNOLOGY, 2018, 200 (07) :2231-2233

[2] Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells [J].

Cerboni, Cristina ;

Ardolino, Michele ;

Santoni, Angela ;

Zingoni, Alessandra .

BLOOD, 2009, 113 (13) :2955-2964

[3] Natural killer cell immunotherapies against cancer: checkpoint inhibitors and more [J].

Chiossone, Laura ;

Vienne, Margaux ;

Kerdiles, Yann M. ;

Vivier, Eric .

SEMINARS IN IMMUNOLOGY, 2017, 31 :55-63

[4] Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity [J].

de Andrade, Lucas Ferrari ;

Tay, Rong En ;

Pan, Deng ;

Luoma, Adrienne M. ;

Ito, Yoshinaga ;

Badrinath, Soumya ;

Tsoucas, Daphne ;

Franz, Bettina ;

May, Kenneth F., Jr. ;

Harvey, Christopher J. ;

Kobold, Sebastian ;

Pyrdol, Jason W. ;

Yoon, Charles ;

Yuan, Guo-Cheng ;

Hodi, F. Stephen ;

Dranoff, Glenn ;

Wucherpfennig, Kai W. .

SCIENCE, 2018, 359 (6383) :1537-+

[5] The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46-and NKG2D-activating receptors and regulates NK-cell function [J].

Della Chiesa, Mariella ;

Carlomagno, Simona ;

Frumento, Guido ;

Balsamo, Mirna ;

Cantoni, Claudia ;

Conte, Romana ;

Moretta, Lorenzo ;

Moretta, Alessandro ;

Vitale, Massimo .

BLOOD, 2006, 108 (13) :4118-4125

[6] NKG2D Ligand-Targeted Bispecific T-Cell Engagers Lead to Robust Antitumor Activity against Diverse Human Tumors [J].

Godbersen, Claire ;

Coupet, Tiffany A. ;

Huehls, Amelia M. ;

Zhang, Tong ;

Battles, Michael B. ;

Fisher, Jan L. ;

Ernstoff, Marc S. ;

Sentman, Charles L. .

MOLECULAR CANCER THERAPEUTICS, 2017, 16 (07) :1335-1346

[7] Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation [J].

Groh, V ;

Wu, J ;

Yee, C ;

Spies, T .

NATURE, 2002, 419 (6908) :734-738

[8] NKG2D Receptor and Its Ligands in Host Defense [J].

Lanier, Lewis L. .

CANCER IMMUNOLOGY RESEARCH, 2015, 3 (06) :575-582

[9] NKG2D ligands in tumor immunity [J].

Nausch, N. ;

Cerwenka, A. .

ONCOGENE, 2008, 27 (45) :5944-5958

[10] Cutting edge: NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment [J].

Roberts, AI ;

Lee, L ;

Schwarz, E ;

Groh, V ;

Spies, T ;

Ebert, EC ;

Jabri, B .

JOURNAL OF IMMUNOLOGY, 2001, 167 (10) :5527-5530

← 1 2 →