Synthesis of THIQ derivatives as potential boron neutron capture therapy agents:: N-functionalized o-carboranylmethyl benzopiperidines

被引：5

作者：

Lee, CH ^{[1
]}

Oh, JM

Lee, JD

Nakamura, H

Ko, J

Kang, SO

机构：

[1] Wonkwang Univ, Dept Bionanochem, Iksan 57074, South Korea

[2] Wonkwang Univ, Inst Basic Nat Sci, Iksan 57074, South Korea

[3] Korea Univ, Dept Chem, Chungnam 339700, South Korea

[4] Gakushuin Univ, Fac Sci, Dept Chem, Tokyo 1718588, Japan

来源：

SYNLETT | 2006年 / 02期

关键词：

BNCT; o-carborane; tetrahydroisoquinoline; 2-aryl-ethylamine; iminium ion;

D O I：

10.1055/s-2006-926222

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for synthesizing o-carborane substituted tetrahydroisoquinolines containing a polar functional group such as sulfonic or phosphoric acid on the nitrogen atom of the piperidine ring, starting from N-(2-arylethyl)sulfamic acid or 2-arylethylamidophosphate, is described. In vitro studies showed that the desired compounds 7a and 10b accumulate to high levels in B-16 melanoma cells despite low cytotoxicity.

引用

页码：275 / 278

页数：4

共 32 条

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