Thyroid Function in Human Obesity: Underlying Mechanisms

被引：104

作者：

Fontenelle, L. C. ^{[1
]}

Feitosa, M. M. ^{[1
]}

Severo, J. S. ^{[1
]}

Freitas, T. E. C. ^{[1
]}

Morais, J. B. S. ^{[1
]}

Torres-Leal, F. L. ^{[2
]}

Henriques, G. S. ^{[3
]}

Marreiro, D. do Nascimento ^{[1
]}

机构：

[1] Univ Fed Piaui, Dept Nutr, Teresina, Piaui, Brazil

[2] Univ Fed Piaui, Dept Physiol & Biophys, Campus Minist Petronio Portela, Teresina, Piaui, Brazil

[3] Univ Fed Minas Gerais, Sch Nursing, Belo Horizonte, MG, Brazil

来源：

HORMONE AND METABOLIC RESEARCH | 2016年 / 48卷 / 12期

关键词：

adipose tissue; thyrotropin; triiodothyronine; thyroxine; BODY-MASS INDEX; DIET-INDUCED OBESITY; SERUM TSH LEVEL; ADIPOSE-TISSUE; STIMULATING HORMONE; INSULIN-RESISTANCE; METABOLIC SYNDROME; IODOTHYRONINE DEIODINASES; LEPTIN RESISTANCE; SUBCUTANEOUS FAT;

D O I：

10.1055/s-0042-121421

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is associated with several metabolic and endocrine disorders; and changes in plasma concentrations, secretion patterns, and clearance of various hormones are observed in obese patients. In this context, recent research has shown that overweight can influence the function of the thyroid gland, usually leading to increased thyrotropin concentrations and changes in the ratio between the hormones triiodothyronine and thyroxine, though within the normal range. The etiology of these changes is still unclear; how-ever, several mechanisms have been proposed including the adaptive process to increase energy expenditure, hyperleptinemia, changes in the activity of deiodinases, the presence of thyroid hormones resistance, chronic low-grade inflammation, and insulin resistance. Although the clinical implications have not been clarified, studies suggest that these changes in the thyroid function of obese individuals may contribute to the worsening of metabolic complications and the development of diseases in the thyroid gland.

引用

页码：787 / 794

页数：8

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