Advances in Rho-dependent actin regulation and oncogenic transformation

被引：76
作者：
Frame, MC
Brunton, VG
机构：
[1] Univ Glasgow, Canc Res Campaign Beatson Labs, Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland
[2] Univ Glasgow, Canc Res Campaign Beatson Labs, Inst Biomed & Life Sci, Glasgow G61 1BD, Lanark, Scotland
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(01)00261-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular movement is central to invasion. The Rho family of small GTPases co-ordinate the cytoskeletal and adhesion modelling within cells that is crucial for normal migratory responses. Consequently, Rho proteins, and their regulators and effectors, are targets for subversion during oncogenic transformation and tumour development. Recent findings have thrown light on how actin regulators may be linked to oncogenesis and the development of cancer.
引用
收藏
页码：36 / 43
页数：8
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