PDA/Cu Bioactive Hydrogel with "Hot Ions Effect" for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing

被引：121
作者：
Xu, Qing [2 ,3 ]
Chang, Mengling [4 ]
Zhang, Yu [2 ,3 ]
Wang, Endian [2 ,3 ]
Xing, Min [2 ,3 ]
Gao, Long [2 ,3 ]
Huan, Zhiguang [2 ,3 ]
Guo, Feng [1 ]
Chang, Jiang [2 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Plast Surg, Affiliated Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Peiformance Ceram & Superfine, Shanghai 200050, Peoples R China
[3] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Burns & Plast Surg, Sch Med, Shanghai 200025, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2020年 / 12卷 / 28期
基金：
中国国家自然科学基金;
关键词：
drug-resistant bacteria; hot ions; PDA/Cu complexing; bioactive hydrogel; infectious skin wound healing; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; COPPER; NANOPARTICLES; COMBINATION; EVOLUTION; EFFICACY; CU; ANGIOGENESIS;
D O I：
10.1021/acsami.0c08890
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Quick and effective sterilization of drug-resistant bacteria inevitably became an ever-growing global challenge. In this study, a multifunctional composite (PDA/Cu-CS) hydrogel mainly composed of polydopamine (PDA) and copper-doped calcium silicate ceramic (Cu-CS) was prepared. It was confirmed that PDA/copper (PDA/Cu) complexing in the composite hydrogel played a key role in enhancing the photothermal performance and antibacterial activity. Through a unique "hot ions effect", created by the heating of Cu ions through the photothermal effect of the composite hydrogel, the hydrogel showed high-efficiency, quick, and long-term inhibition of methicillin-resistant Staphylococcus aureus and Escherichia coli. In addition, the hydrogel possessed remarkable bioactivity to stimulate angiogenesis. The in vivo results confirmed that the "hot ions effect" of the composite hydrogel removed existing infection in the wound area efficiently and significantly promoted angiogenesis and collagen deposition during infectious skin wound healing. Our results suggested that the design of multifunctional hydrogels with "hot ions effect" may be an effective therapeutic approach for the treatment of infectious wounds.
引用
收藏
页码：31255 / 31269
页数：15
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