The Cerebrospinal Fluid in Multiple Sclerosis

被引：129

作者：

Deisenhammer, Florian ^{[1
]}

Zetterberg, Henrik ^{[2
,3
,4
,5
]}

Fitzner, Brit ^{[6
]}

Zettl, Uwe K. ^{[6
]}

机构：

[1] Innsbruck Med Univ, Dept Neurol, Innsbruck, Austria

[2] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden

[3] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[4] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[5] UK Dementia Res Inst UCL, Fluid Biomarker Lab, London, England

[6] Univ Med Rostock, Dept Neurol, Div Neuroimmunol, Rostock, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

CSF (cerebrospinal fluid); biomarker; multiple sclerosis; oligoclonal band (OCB); neurofilament light (NfL); CLINICALLY ISOLATED SYNDROME; INTRATHECAL IGM-SYNTHESIS; SOLUBLE ADHESION MOLECULES; NEUROFILAMENT LIGHT-CHAIN; OLIGOCLONAL BANDS; DISEASE-ACTIVITY; AXONAL DAMAGE; NATALIZUMAB TREATMENT; NEUROMYELITIS-OPTICA; DIAGNOSTIC-CRITERIA;

D O I：

10.3389/fimmu.2019.00726

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Investigation of cerebrospinal fluid (CSF) in the diagnostic work-up in suspected multiple sclerosis (MS) patients has regained attention in the latest version of the diagnostic criteria due to its good diagnostic accuracy and increasing issues withmisdiagnosis ofMS based on over interpretation of neuroimaging results. The hallmark of MS-specific changes in CSF is the detection of oligoclonal bands (OCB) which occur in the vast majority of MS patients. Lack of OCB has a very high negative predictive value indicating a red flag during the diagnostic work-up, and alternative diagnoses should be considered in such patients. Additional molecules of CSF can help to support the diagnosis of MS, improve the differential diagnosis of MS subtypes and predict the course of the disease, thus selecting the optimal therapy for each patient.

引用

页数：10

共 108 条

[1] Neuromyelitis Optica in Austria in 2011: To Bridge the Gap between Neuroepidemiological Research and Practice in a Study Population of 8.4 Million People [J].

Aboul-Enein, Fahmy ;

Seifert-Held, Thomas ;

Mader, Simone ;

Kuenz, Bettina ;

Lutterotti, Andreas ;

Rauschka, Helmut ;

Rommer, Paulus ;

Leutmezer, Fritz ;

Vass, Karl ;

Flamm-Horak, Agathe ;

Stepansky, Robert ;

Lang, Wilfried ;

Fertl, Elisabeth ;

Schlager, Thomas ;

Heller, Thomas ;

Eggers, Christian ;

Safoschnik, Georg ;

Fuchs, Siegrid ;

Kraus, Joerg ;

Assar, Hamid ;

Guggenberger, Stefan ;

Reisz, Martin ;

Schnabl, Peter ;

Komposch, Martina ;

Simschitz, Philipp ;

Skrobal, Alena ;

Moser, Alexander ;

Jeschow, Mario ;

Stadlbauer, Dorothea ;

Freimueller, Manfred ;

Guger, Michael ;

Schmidegg, Susanne ;

Franta, Claudia ;

Weiser, Vera ;

Koppi, Stefan ;

Niederkorn-Duft, Margret ;

Raber, Bettina ;

Schmeissner, Iris ;

Jecel, Julia ;

Tinchon, Alexander ;

Storch, Maria K. ;

Reindl, Markus ;

Berger, Thomas ;

Kristoferitsch, Wolfgang .

PLOS ONE, 2013, 8 (11)

[2] Intrathecal sICAM-1 production in multiple sclerosis -: Correlation with triple dose Gd-DTPA MRI enhancement and IgG index [J].

Acar, G ;

Idiman, F ;

Kirkali, G ;

Özakbas, S ;

Oktay, G ;

Çakmakçi, H ;

Idiman, E .

JOURNAL OF NEUROLOGY, 2005, 252 (02) :146-150

[3] CEREBROSPINAL-FLUID IN THE DIAGNOSIS OF MULTIPLE-SCLEROSIS - A CONSENSUS REPORT [J].

ANDERSSON, M ;

ALVAREZCERMENO, J ;

BERNARDI, G ;

COGATO, I ;

FREDMAN, P ;

FREDERIKSEN, J ;

FREDRIKSON, S ;

GALLO, P ;

GRIMALDI, LM ;

GRONNING, M ;

KEIR, G ;

LAMERS, K ;

LINK, H ;

MAGALHAES, A ;

MASSARO, AR ;

OHMAN, S ;

REIBER, H ;

RONNBACK, L ;

SCHLUEP, M ;

SCHULLER, E ;

SINDIC, CJM ;

THOMPSON, EJ ;

TROJANO, M ;

WURSTER, U .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1994, 57 (08) :897-902

[4]

[Anonymous], 2012, 151892012 ISO, P1

[5] Quantitation of intrathecal immunoglobulin synthesis - a new empirical formula [J].

Auer, M. ;

Hegen, H. ;

Zeileis, A. ;

Deisenhammer, F. .

EUROPEAN JOURNAL OF NEUROLOGY, 2016, 23 (04) :713-721

[6] Protein biomarkers for multiple sclerosis: semi-quantitative analysis of cerebrospinal fluid candidate protein biomarkers in different forms of multiple sclerosis [J].

Avsar, Timucin ;

Korkmaz, Didem ;

Tutuncu, Melih ;

Demirci, N. Onat ;

Saip, Sabahattin ;

Kamasak, Mustafa ;

Siva, Aksel ;

Turanli, Eda Tahir .

MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (08) :1081-1091

[7] Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis [J].

Axelsson, M. ;

Malmestrom, C. ;

Nilsson, S. ;

Haghighi, S. ;

Rosengren, L. ;

Lycke, J. .

JOURNAL OF NEUROLOGY, 2011, 258 (05) :882-888

[8] Cerebrospinal fluid NCAM levels are modulated by disease-modifying therapies [J].

Axelsson, Markus ;

Dubuisson, Nicolas ;

Novakova, Lenka ;

Malmestrom, Clas ;

Giovannoni, Gavin ;

Lycke, Jan ;

Gnanapavan, Sharmilee .

ACTA NEUROLOGICA SCANDINAVICA, 2019, 139 (05) :422-427

[9] Immunosuppressive therapy reduces axonal damage in progressive multiple sclerosis [J].

Axelsson, Markus ;

Malmestrom, Clas ;

Gunnarsson, Martin ;

Zetterberg, Henrik ;

Sundstrom, Peter ;

Lycke, Jan ;

Svenningsson, Anders .

MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (01) :43-50

[10] Anti-JC virus antibody index changes in rituximab-treated multiple sclerosis patients [J].

Baber, Ursela ;

Bouley, Andrew ;

Egnor, Emily ;

Sloane, Jacob A. .

JOURNAL OF NEUROLOGY, 2018, 265 (10) :2342-2345

← 1 2 3 4 5 6 7 8 9 10 →