Additive Manufactured Magnesium-Based Scaffolds for Tissue Engineering

被引：27

作者：

Antoniac, Iulian ^{[1
,2
]}

Manescu , Veronica ^{[1
,3
]}

Paltanea, Gheorghe ^{[3
]}

Antoniac, Aurora ^{[1
]}

Nemoianu, Iosif Vasile ^{[3
]}

Petrescu, Mircea Ionut ^{[1
]}

Dura, Horatiu ^{[4
]}

Bodog, Alin Danut ^{[5
]}

机构：

[1] Univ Politehn Bucuresti, Fac Mat Sci & Engn, 313 Splaiul Independentei, Bucharest 060042, Romania

[2] Acad Romanian Scientists, 54 Splaiul Independentei, Bucharest 050094, Romania

[3] Univ Politehn Bucuresti, Fac Elect Engn, 313 Splaiul Independentei, Bucharest 060042, Romania

[4] Lucian Blaga Univ Sibiu, Fac Med, Sibiu 550169, Romania

[5] Univ Oradea, Fac Med & Pharm, 10 P-ta 1 December St, Oradea 410073, Romania

来源：

MATERIALS | 2022年 / 15卷 / 23期

关键词：

Mg-based scaffolds; tissue engineering; additive manufacturing; bone defect treatment; regenerative medicine; bioresorbable implants; computer-aided design; IN-VITRO DEGRADATION; MG-CA ALLOYS; NACL TEMPLATES RELATIONSHIP; OF-THE-ART; MECHANICAL-PROPERTIES; POROUS MAGNESIUM; BIODEGRADABLE MAGNESIUM; ORTHOPEDIC IMPLANTS; 3-DIMENSIONAL SCAFFOLDS; DENSIFICATION BEHAVIOR;

D O I：

10.3390/ma15238693

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Additive manufacturing (AM) is an important technology that led to a high evolution in the manufacture of personalized implants adapted to the anatomical requirements of patients. Due to a worldwide graft shortage, synthetic scaffolds must be developed. Regarding this aspect, biodegradable materials such as magnesium and its alloys are a possible solution because the second surgery for implant removal is eliminated. Magnesium (Mg) exhibits mechanical properties, which are similar to human bone, biodegradability in human fluids, high biocompatibility, and increased ability to stimulate new bone formation. A current research trend consists of Mg-based scaffold design and manufacture using AM technologies. This review presents the importance of biodegradable implants in treating bone defects, the most used AM methods to produce Mg scaffolds based on powder metallurgy, AM-manufactured implants properties, and in vitro and in vivo analysis. Scaffold properties such as biodegradation, densification, mechanical properties, microstructure, and biocompatibility are presented with examples extracted from the recent literature. The challenges for AM-produced Mg implants by taking into account the available literature are also discussed.

引用

页数：33