Cardiovascular aging: the unveiled enigma from bench to bedside

被引：10

作者：

Cannata', Antonio ^{[1
,2
,3
]}

Merlo, Marco ^{[1
,2
]}

Artico, Jessica ^{[1
,2
]}

Gentile, Piero ^{[1
,2
]}

Camparini, Luca ^{[3
]}

Cristallini, Jacopo ^{[1
,2
]}

Porcari, Aldostefano ^{[1
,2
]}

Loffredo, Francesco ^{[1
,2
,3
]}

Sinagra, Gianfranco ^{[1
,2
]}

机构：

[1] Azienda Sanit Univ Integrata Trieste, Cardiovasc & Thorac Dept, Via Pietro Valdoni 7, I-34100 Trieste, Italy

[2] Univ Trieste, Via Pietro Valdoni 7, I-34100 Trieste, Italy

[3] Int Ctr Genet Engn & Biotechnol, Trieste, Italy

来源：

JOURNAL OF CARDIOVASCULAR MEDICINE | 2018年 / 19卷 / 10期

关键词：

aging cardiomyopathy; calcium handling; cardiovascular aging; heart failure with preserved ejection fraction; myocyte hypertrophy; PRESERVED EJECTION FRACTION; AGE-RELATED-CHANGES; VENTRICULAR DIASTOLIC FUNCTION; HEART-FAILURE; SARCOPLASMIC-RETICULUM; ANGIOTENSIN-II; EXTRACELLULAR-MATRIX; MYOCARDIAL FIBROSIS; OXIDATIVE STRESS; TISSUE INHIBITOR;

D O I：

10.2459/JCM.0000000000000694

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The rapid increase in the median age of the world's population requires particular attention towards older and more fragile people. Cardiovascular risk factors, time and comorbidities play a vicious role in the development of heart failure, both with reduced and preserved ejection fraction, in the elderly. Understanding the mechanisms underlying the pathophysiological processes observed with aging is pivotal to target those patients and their therapeutic needs properly. This review aims to investigate and to dissect the main pathways leading to the aging cardiomyopathy, helping to understand the relationship from bench to bedside of the clinical phenotype.

引用

页码：517 / 526

页数：10

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