MicroRNAs in apoptosis, autophagy and necroptosis

被引：326
作者：
Su, Zhenyi [1 ,2 ]
Yang, Zuozhang [3 ]
Xu, Yongqing [4 ]
Chen, Yongbin [5 ]
Yu, Qiang [6 ]
机构：
[1] Southeast Univ, Sch Med, Dept Biochem & Mol Biol, Nanjing 210009, Jiangsu, Peoples R China
[2] Harvard Univ, Dept Cell Biol, Sch Med, Boston, MA 02115 USA
[3] Kunming Med Univ, Tumor Hosp Yunnan Prov, Bone & Soft Tissue Tumors Res Ctr Yunnan Prov, Dept Orthopaed,Affiliated Hosp 3, Kunming 650118, Yunnan, Peoples R China
[4] Chengdu Mil Command, Kunming Gen Hosp, Dept Orthopaed, Kunming 650118, Yunnan, Peoples R China
[5] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
[6] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
来源：
ONCOTARGET | 2015年 / 6卷 / 11期
基金：
中国国家自然科学基金;
关键词：
microRNA; apoptosis; autophagy; necroptosis; cancer progression; HEPATOCELLULAR-CARCINOMA CELLS; SUPPRESSES TUMOR-GROWTH; BREAST-CANCER CELLS; BCL-X-L; PROMOTES APOPTOSIS; COLORECTAL-CANCER; DOWN-REGULATION; PANCREATIC-CANCER; SIGNALING PATHWAYS; MEDIATED CLEAVAGE;
D O I：
10.18632/oncotarget.3523
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for cleavage or translational repression. Numerous miRNAs regulate programmed cell death including apoptosis, autophagy and necroptosis. We summarize how miRNAs regulate apoptotic, autophagic and necroptotic pathways and cancer progression. We also discuss how miRNAs link different types of cell death.
引用
收藏
页码：8474 / 8490
页数：17
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