DNA topoisomerases

被引：2017
作者：
Wang, JC
机构：
[1] Dept. of Molec. and Cellular Biology, Harvard University, Cambridge
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 1996年 / 65卷
关键词：
enzyme mechanism; DNA topology; DNA-protein interaction; DNA-protein covalent complexes; replication; transcription; gyrase; genome stability; chromosome condensation; chromosome segregation;
D O I：
10.1146/annurev.bi.65.070196.003223
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA topoisomerases, have evolved to solve these problems. This review focuses on work in the past decade on the mechanisms and cellular functions of these enzymes. Newly discovered members and recent biochemical and structural results are reviewed, and mechanistic implications of these results are summarized. The primary cellular functions of these enzymes, including their roles in replication, transcription, chromosome condensation, and the maintenance of genome stability, are then discussed. The review ends with a summary of the regulation of the cellular levels of these enzymes and a discussion of their association with other cellular proteins.
引用
收藏
页码：635 / 692
页数：58
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