A mild, efficient method for the synthesis of aromatic and aliphatic sulfonamides

被引：44

作者：

Chan, WY ^{[1
]}

Berthelette, C ^{[1
]}

机构：

[1] Merck Frosst Ctr Therapeut Res, Dept Med Chem, Pointe Claire, PQ H9R 4P8, Canada

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 25期

关键词：

sulfonamides; azodicarboxylate; sulfinate; sulfonylhydrazide; reductive cleavage;

D O I：

10.1016/S0040-4039(02)00848-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-step method was developed for the synthesis of aromatic and aliphatic sulfonamides from the corresponding sulfinates using bis(2,2,2-trichloroethyl)azodicarboxylate as the electrophilic nitrogen source. The intermediate sulfonylhydrazides were obtained in very good yields and were cleaved under reductive conditions to deliver the desired sulfonamides. A variety of substituents in the aromatic ring are well tolerated as well as heterocycles. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：4537 / 4540

页数：4

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