Solventless Synthesis of N-Protected Amino Acids in a Ball Mill

被引：51

作者：

Konnert, Laure ^{[1
]}

Gauliard, Anne ^{[1
]}

Lamaty, Frederic ^{[1
]}

Martinez, Jean ^{[1
]}

Colacino, Evelina ^{[1
]}

机构：

[1] Univ Montpellier 2, UMR CNRS UM 1 UM 2 5247, IBMM, F-34095 Montpellier 5, France

来源：

ACS SUSTAINABLE CHEMISTRY & ENGINEERING | 2013年 / 1卷 / 09期

关键词：

Amino Acids; Ball mill; Protective groups; Solvent free; E-factor; NUCLEOSIDE; ANALOGS; ESTERS;

D O I：

10.1021/sc4001115

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An eco-friendly methodology for preparing carbamate N-protected alpha-amino acids is described using ball-milling technology. Some beta-amino acids were also investigated in this study. This solvent-free methodology gave Boc-, Z-, and Fmoc-N-protected compounds in good to excellent yields with improved environmental impact compared to classical syntheses in solution. Different planetary ball mills were employed. The results are also discussed according to the different process parameters (grinding material, number of balls, rotation speed).

引用

页码：1186 / 1191

页数：6

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