Protective effect of exogenous matrix metalloproteinase-9 on chronic renal failure

被引：15

作者：

Wang, Lei ^{[1
]}

Wang, Jue ^{[1
]}

Wang, Yong ^{[2
]}

Fu, Qiang ^{[2
]}

Lei, Yong-Hua ^{[2
]}

Nie, Zhi-Yong ^{[3
]}

Qiu, Jianxin ^{[2
]}

Bao, Ting-Yi ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Tangdu Hosp, Dept Urol Surg, Inst Infect Dis, Xian 710078, Shaanxi, Peoples R China

[2] Fourth Mil Med Univ, Tangdu Hosp, Dept Urol Surg, Xian 710078, Shaanxi, Peoples R China

[3] Tenth Hosp PLA, Dept Urol Surg, Wuwei 733000, Gansu, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2014年 / 7卷 / 02期

关键词：

chronic renal failure; TIMP-1; MMP-9; adenine; MATRIX METALLOPROTEINASE-2 AND-9; CHRONIC KIDNEY-DISEASE; TISSUE INHIBITORS; GROWTH-FACTOR; TIMP-1; EXPRESSION; FIBROSIS; INJURY; MODEL; MMP-9;

D O I：

10.3892/etm.2013.1409

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have pivotal functions in extracellular matrix turnover and are involved in chronic kidney diseases. However, the exact functions of MMPs in chronic renal failure (CRF) have yet to be demonstrated. The aim of the present study was to examine the effects of MMP-9 on CRF. An adenine-induced model of CRF was generated in rabbits. Following the injection of MMP-9 into the renal arteries of the rabbits, significant improvements in renal morphology and serum levels of creatinine and urea nitrogen were observed. Furthermore, MMP-9 administration was shown to decrease the serum TIMP-1 concentration and upregulate renal MMP-9 expression. These results demonstrate a directly protective role for MMP-9 in CRF.

引用

页码：329 / 334

页数：6

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