Grey theory is broadly applied to model and prediction of systems that characterized by poor information. The GM residual model is more adaptive to practical forecasting than GM(1,1) due to the precision problem. However, the potency of residual series depends on the number of data points with the same sign. This paper presents a technique that combines residual modification with artificial neural network sign estimation, which widens residual model's application range. Also, based on the combining forecasting theory, an integrated ANN and grey model were be defined which Supplies an effective method for further improving prediction accuracy.