Acute respiratory tract infections due to a human metapneumovirus in children: descriptive study and comparison with respiratory syncytial virus infections

被引：14
作者：
Bach, N
Cuvillon, D
Brouard, J
Lafay, F
Freymuth, F
Legrand, L
Guillois, B
Duhamel, JF
机构：
[1] CHU Clemenceau, Serv Pediat, F-14033 Caen, France
[2] Ctr Hosp Jacques Monod, Serv Pediat, F-61100 Flers, France
[3] CHU Clemenceau, Lab Virol Humaine & Mol, F-14033 Caen, France
来源：
ARCHIVES DE PEDIATRIE | 2004年 / 11卷 / 03期
关键词：
metapneumovirus; pathogenicity; respiratory tract infections; bronchiolitis; viral; child;
D O I：
10.1016/j.arcped.2003.12.009
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Background. - A new paramyxovirus, the human metapneumovirus was recently isolated. We report the first French cases collected between 2000 and 2002. Material and methods. - Samples were obtained from nasopharyngeal aspirates from children hospitalised for acute respiratory tract infection in hospitals of Caen and Flers in Basse-Normandie. Human metapneumovirus was studied by polymerase chain reaction on negative samples for respiratory syncytial virus, influenza A and B virus, parainfluenza (1, 2 and 3) virus, adenovirus, coronavirus and rhinovirus. Comparison between metapneumovirus virus and respiratory syncytial virus infections was done after matching sex, age and infection month. Results. - Twenty-six human metapneumovirus infections were identified. A comparative study of a matched group of children infected by respiratory syncytial virus found no significative difference for hospitalisation motive, clinical criteria and treatment. Conclusion. - The human metapneurnovirus is responsible for typical acute bronchiolitis in children. (C) 2003 Elsevier SAS. Tous droits reserves.
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收藏
页码：212 / 215
页数：4
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